365 Episoden
Why Everything Feels Harder After 40: Nervous System, Burnout & Letting Go
26.08.2026 | 1 Std. 21 Min.What if the changes you’re experiencing after 40 are asking you to look at more than your hormones?
In this solo episode of Live Like a Girl, Dr. Mindy walks through how she believes women can use the menopausal transition to better understand their nervous systems, reconnect with parts of themselves they may have lost, and begin building the next chapter of life more intentionally.
She explores why so many women arrive in midlife already overwhelmed, why learning to regulate your nervous system may need to come before another health protocol, and how years of putting everyone else first can shape the way women experience this transition.
Later in the episode, LeAnn Rimes joins Dr. Mindy for a candid conversation about overwhelm, perfectionism, boundaries, HRT, nutrition, self-care, and what it looks like to listen to your body while living a very full life.
And for a limited time, you can get Age Like a Girl for $7 with free shipping in the U.S. and Canada only, while supplies last.
In This Episode, You’ll Learn
Why nervous system regulation matters so much after 40
How years of over-functioning can catch up with women in midlife
Why play, curiosity, creativity, and speaking your truth matter
How to build your own lifestyle toolbox for menopause
Why women need community as they age
Why saying no can become an important form of self-care
What it means to create the next chapter of your life on your terms
Resources Mentioned
FREE Nervous System Questionnaire
Age Like a Girl (Get your copy for $7 & FREE shipping, limited-time offer)
Reset Academy
Qualia Senolytic, use code MINDY for 15% off
For more resources related to today’s episode, visit the podcast episode page: drmindypelz.com/ep364
Connect with Dr. Mindy:
Join Reset Academy
Watch the episodes on YouTube
Follow Dr. Mindy on Instagram
Subscribe to Dr. Mindy’s newsletter
Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.- Women are far more likely than men to develop Alzheimer’s disease, and Dr. David Perlmutter believes one of the most important pieces of that story is metabolic health.
In this episode of Live Like a Girl, Dr. Perlmutter joins Dr. Mindy to explain what happens when the brain’s immune cells shift from protective to destructive, why menopause may increase vulnerability, and how blood sugar, insulin resistance, visceral fat, inflammation, mitochondrial health, and lifestyle all influence brain aging.
They also discuss HRT, GLP-1 medications, ketones, fasting, fiber, exercise, BNDF, sleep, and what women can begin doing in their 30s, 40s, and 50s to support long-term cognitive health.
In This Episode, You’ll Learn
Why women face a higher risk of Alzheimer’s
How menopause may affect brain metabolism
Why belly fat and insulin resistance matter for brain health
The blood markers Dr. Perlmutter watches most closely
What emerging research says about GLP-1 drugs and the brain
The lifestyle habits Dr. Perlmutter prioritizes for prevention
Resources Mentioned
Brain Defenders
Tanzi Study
Cochrane Review
More on Dr. David Perlmutter
https://drperlmutter.com/
http://braindefenders.com/
https://www.instagram.com/davidperlmutter/
https://www.youtube.com/user/DavidPerlmutterMD
https://x.com/davidperlmutter
linkedin.com/in/david-perlmutter-md
For more resources related to today’s episode, visit the podcast episode page: https://www.drmindypelz.com/ep363/
Connect with Dr. Mindy:
Join Reset Academy
Watch the episodes on YouTube
Follow Dr. Mindy on Instagram
Subscribe to Dr. Mindy’s newsletter
Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle. - If you’re eating less, exercising more, and fasting harder but still struggling to lose weight after 40, Dr. Mindy wants you to approach fat loss differently. This solo episode of Live Like a Girl is a special compilation of two of Dr. Mindy’s teachings on fat burning and metabolic health after 40.
In the first half, she breaks down why fat loss can become more challenging as estrogen changes and shares five strategies for training your body to become more metabolically flexible, from strength training and walking to fasting, protein pacing, and sleep.
Then she turns to dietary fat and explains why the type of fat you eat matters. She walks through visceral fat, omega fatty acids, and five foods she uses to support a healthier metabolic environment.
The common thread throughout both conversations: fat loss after 40 requires a strategy that works with your changing metabolism.
In This Episode, You’ll Learn
Why fat loss can become harder after 40
How estrogen influences metabolism and body-fat distribution
What protein pacing means and how Mindy uses it
Why walking is an underrated metabolic tool
The difference between visceral and subcutaneous fat
Why Mindy pays attention to the types of dietary fats she eats
Five foods she recommends adding to a fat-loss strategy
Resources Mentioned:
Fresh Pressed Olive Oil
MCT Oil
For more resources related to today’s episode, visit the podcast episode page: drmindypelz.com/ep362
Connect with Dr. Mindy:
Join Reset Academy
Watch the episodes on YouTube
Follow Dr. Mindy on Instagram
Subscribe to Dr. Mindy’s newsletter
Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle. - Laila Ali spent years training to win. As an undefeated professional boxer, her body was her career. She knew exactly how to train harder, eat less, and make weight when she needed to. Then perimenopause changed the rules.
In this episode of Live Like a Girl, Laila joins Dr. Mindy for an honest conversation about what happened when her old strategies stopped working, why she eventually stopped trying to outwork her hormones, and how fasting helped her build a completely different relationship with her body.
They talk about long fasts, exercising while fasting, food noise, refeeding, sugar cravings, body image, the scale, stress, and what it means to train for health instead of performance.
Laila also shares how she talks to her teenage daughter about fasting, why she refuses to make healthy eating feel like punishment, and the lesson she learned from becoming a boxer against Muhammad Ali’s wishes: sometimes the most important thing you can do is listen to the spark inside you.
In this episode, you'll learn:
Why Laila stopped trying to outwork her hormones
How fasting changed her relationship with food and control
What she learned from doing longer fasts
How she exercises during a fast
Why refeeding matters after an extended fast
How she thinks about weight, muscle, and body image now
Why stress can derail even strong health routines
How she talks to her daughter about fasting
Why she no longer counts macros
What Muhammad Ali taught her about following your own path
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Resources & Supplements Mentioned
A Spark of Greatness by Laila Ali
Laila's Organic Spice Blends
Zero Fasting App
Fast Like a Girl
Qualia Creatine+ (use code MINDY for 15% off)
Infrared Sauna
Red Light Therapy
Electrolytes
Bone Broth (use code MINDY10 for 10% off)
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More on Laila Ali
A Spark of Greatness by Laila Ali
Laila's Organic Spice Blends
Food for Life by Laila Ali
Website: lailaali.com
Instagram: @thereallailaali
Facebook: @LailaAli
For more resources related to today’s episode, visit the podcast episode page: drmindypelz.com/ep361
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Connect with Dr. Mindy:
Join Reset Academy
Watch the episodes on YouTube
Follow Dr. Mindy on Instagram
Subscribe to Dr. Mindy’s newsletter for tools and research on fasting, hormones, and metabolic health
Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle. - Healing your nervous system does not always feel peaceful at first.
In this solo episode of Live Like a Girl, Dr. Mindy explains why fatigue, crying, irritability, digestive changes, and even discomfort with stillness can sometimes show up as your nervous system begins moving out of a chronically activated state.
She breaks down the relationship between heart rate variability, vagal tone, the sympathetic and parasympathetic nervous systems, and why learning to move more easily between stress and recovery may be one of the most important skills you can build for your health.
Resources Mentioned
FREE Nervous System Questionnaire
Qualia Magnesium
Reset Academy
Find a Fast Like a Girl Coach
In this episode you'll learn:
Why increased fatigue may appear when your body finally begins resting
Why crying and irritability can surface during nervous system healing
How your digestion reflects your nervous system state
Why stillness can feel unsafe when your body is accustomed to constant activation
How 4-7-8 breathing can support the parasympathetic nervous system
Why nature can be one of the simplest nervous system tools
How magnesium and sleep routines may help
Why humming, gargling, and chanting can support vagal tone
When getting support from a practitioner or community may be helpful
For more resources related to today’s episode, visit the podcast episode page: drmindypelz.com/ep360
Connect with Dr. Mindy:
Join Reset Academy
Watch the episodes on YouTube
Follow Dr. Mindy on Instagram
Subscribe to Dr. Mindy’s newsletter
Disclaimer: This podcast is intended for educational and informational purposes only and is not a substitute for professional medical advice. Always consult a qualified healthcare professional before making changes to your diet, fasting routine, or lifestyle.
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Über Live Like a Girl with Dr. Mindy Pelz
We were taught that doing anything "like a girl" was a weakness. Dr. Mindy Pelz is here to prove it's your greatest strength.
A renowned advocate for women's health, Dr. Mindy is passionately committed to helping women embrace and trust their body's natural healing processes. Drawing on an extensive background in women's health, she's developed groundbreaking, science-backed approaches that help women work with their hormones, not against them, through every stage of life, from cycling to perimenopause to the wisdom of the years beyond.
On Live Like a Girl, Dr. Mindy helps you come home to your own body. Every Monday, she sits down with some of the brightest minds in health and wellness for honest, meaningful conversations that hand you the knowledge, tools, and science to do health your way. No more pushing through, gaslighting yourself, or shrinking to fit. Just permission to live in rhythm with the body you were designed to have and to finally feel at home in it.
Press play, and let's live like a girl.
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