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The Dr. Hyman Show

Dr. Mark Hyman
The Dr. Hyman Show
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  • From Chemical Imbalance to Metabolic Breakthrough: A New Path for Mental Health
    Many psychiatric labels—like bipolar disorder and schizophrenia—can obscure underlying biology, and symptom checklists often fail to explain or heal what’s really going on. Emerging evidence reframes mental illness as a problem of brain energy, mitochondria, and inflammation—shaped by insulin signaling, circadian rhythm disruption, the gut–brain axis, toxins, infections, and nutrient status. Metabolic interventions such as ketogenic nutrition, already established for epilepsy, show promise for rebalancing neurotransmitters, lowering neuroinflammation, and improving overall brain function. With depression now a leading cause of disability, shifting from “manage the symptoms” to “fix the biology” could dramatically improve outcomes where standard drugs fall short. In this episode, Dr. Christopher Palmer, Dr. Todd LePine, Dr. Iain Campbell and I explore how rethinking mental illness as a metabolic and inflammatory disorder of the brain—rather than just a chemical imbalance—could transform the treatment and prevention of conditions like depression, bipolar disorder, and schizophrenia. Dr. Chris Palmer is a psychiatrist and researcher working at the interface of metabolism and mental health. He is the Director of the Department of Postgraduate and Continuing Education at McLean Hospital and an Assistant Professor of Psychiatry at Harvard Medical School. For over 25 years, he has held leadership roles in psychiatric education, conducted research, and worked with people who have treatment-resistant mental illnesses. He has been pioneering the use of the medical ketogenic diet in the treatment of psychiatric disorders - conducting research in this area, treating patients, writing, and speaking around the world on this topic. More broadly, he is interested in the roles of metabolism and metabolic interventions on brain health. Dr. Todd LePine graduated from Dartmouth Medical School and is Board Certified in Internal Medicine, specializing in Integrative Functional Medicine. He is an Institute for Functional Medicine Certified Practitioner. Prior to joining The UltraWellness Center, he worked as a physician at Canyon Ranch in Lenox, MA, for 10 years. Dr. LePine’s focus at The UltraWellness Center is to help his patients achieve optimal health and vitality by restoring the natural balance to both the mind and the body. His areas of interest include optimal aging, bio-detoxification, functional gastrointestinal health, systemic inflammation, autoimmune disorders, and the neurobiology of mood and cognitive disorders.  Dr. lain Campbell is the first academic research fellow to specialise in Metabolic Psychiatry as the Baszucki Research Fellow in Metabolic Psychiatry at the University of Edinburgh. He has a PhD in Global Health from the University of Edinburgh and is a principal investigator on a pilot trial of a ketogenic diet for bipolar disorder. He is a workstream lead and co-investigator on the first publicly funded research hub for Metabolic Psychiatry, the UKRI Medical Research Council Hub for Metabolic Psychiatry at the University of Edinburgh. His research in metabolic psychiatry has been published in Nature press journals Molecular Psychiatry and Translational Psychiatry and presented at Mayo Clinic Grand Rounds and The Royal College of Psychiatrists International Congress.  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:A Harvard Psychiatrist Rethinks Mental Health As A Metabolic Disease Is Brain Inflammation The Cause of Depression, Dementia, ADD, And Autism? A Functional Medicine Approach To Neuroinflammation Is Bipolar Disorder Really a Diet Problem?
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  • From Drug Smuggler to Healer: How Nick Brewer Created Primal Moves
    On this episode of The Dr. Hyman Show, I sit down with Nick Brewer, founder of Primal Moves—a method born from his own healing journey. Once a pro skier turned drug smuggler, he spent ten years in prison, including four in solitary, where he discovered the power of breath and movement to rebuild his body and mind. I had the chance to try Nick’s class myself, and I was struck by how powerful such simple movements can be. I’m excited to share that experience with you. You can watch the full conversation on YouTube, or listen wherever you get your podcasts. [YOUTUBE THUMBNAIL] We discuss: • How to spot when your nervous system is stuck—and steps to restore balance • Why talk therapy alone can’t release trauma in the body • How group movement triggers natural feel-good brain chemistry • Why we feel cut off from our bodies and how to reconnect Healing starts in the body. By working through stress and pain, we gain the strength and energy to show up fully in life. My hope is that this conversation encourages you to explore these practices and see what they unlock for you. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Resultshttps://drhyman.com/pages/hyman-hive This episode is brought to you by BON CHARGE, Timeline, Function Health, Big Bold Health, Paleovalley and LMNT. Head to boncharge.com and use code DRMARK for 15% off your order. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Get 30% off HTB Immune Energy Chews at bigboldhealth.com and use code DRMARK30. Get nutrient-dense, whole foods. Head to paleovalley.com/hyman for 15% off your first purchase. Get a free LMNT Sample Pack with any order—just head to drinklmnt.com/hyman.
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  • The Silent Fire Behind Chronic Disease—and How to Put It Out
    Inflammation is the body’s natural way of healing, but when it becomes chronic and hidden, it quietly drives many of today’s most common health problems—heart disease, diabetes, dementia, cancer, autoimmune conditions, and more. Unlike the redness and swelling from a cut or sprain, this “silent inflammation” often goes unnoticed while slowly damaging tissues and speeding up aging. Modern life fuels the fire: processed foods, food additives, pollution, plastics, chronic stress, too much sitting, and poor sleep. The good news is inflammation can be calmed by simple daily choices—eating colorful whole foods like berries, leafy greens, beans, nuts, seeds, and omega-3 rich fish; adding herbs and spices like turmeric and cumin; moving regularly; practicing relaxation; and repairing gut health. Even small shifts, like climbing stairs, eating within a shorter window, or reducing sugar, can make a big difference. By lowering inflammation, the body finds balance again, opening the door to more energy, resilience, and healthy aging. In this episode, I discuss, along with Dr. Shilpa Ravella and Dr. David Furman, why it’s important to be aware of systemic inflammation and how to address it. Dr. Ravella is a gastroenterologist and Assistant Professor of Medicine at Columbia University Medical Center. She is the author of A Silent Fire: The Story of Inflammation, Diet & Disease, which investigates inflammation—the hidden force at the heart of modern disease. Her writing has appeared in The Atlantic, New York Magazine, The Wall Street Journal, TIME, Slate, Discover, and USA Today, among other publications.  Dr. David Furman is Associate Professor and Director of the Bioinformatics Core at the Buck Institute for Research on Aging, as well as the Director of the Stanford 1000 Immunomes Project. He obtained his doctoral degree in immunology from the School of Medicine, University of Buenos Aires, Argentina, for his work on cancer immune-surveillance. During his postdoctoral training at the Stanford School of Medicine, Dr. Furman focused on the application of advanced analytics to study the aging of the immune system in humans. He has published nearly thirty scientific articles in top-tier journals such as Cell, Nature Medicine, PNAS, The Lancet, and others.  This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here:What Causes Inflammation And How Can You Treat It? The Silent Killer: Inflammation And Chronic Disease How Silent Inflammation Accelerates Aging
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  • One Dose That Heals Addiction, PTSD, and Brain Injury? Dr. Nolan Williams on The Science of Ibogaine
    For decades, psychiatry has relied on treatments that are slow and often ineffective. But what if one intervention could reset the brain, break the grip of addiction, and open the door to an entirely new model of care? On this episode of The Dr. Hyman Show, I sit down with Dr. Nolan Williams, a Stanford neuropsychiatrist pioneering new therapies for substance use disorders, depression, PTSD, and traumatic brain injury. We dive into these fascinating topics and more; watch the full conversation on YouTube or listen wherever you get your podcasts. You’ll learn: • Why ibogaine is unlike any other psychedelic—and how it could reset the brain • Its promise for treating substance abuse disorders and breaking cycles of addiction • The safety step that makes ibogaine treatment possible for real patients • Why psychiatry is shifting from trial-and-error to targeted brain circuits Talks like this remind me just how close we are to real breakthroughs in mental health. Dr. Williams calls it psychiatry 3.0. It’s a new era of treatments that actually heal the brain, and it gives me great hope for the future of medicine. View Show Notes From This Episode Get Free Weekly Health Tips from Dr. Hyman https://drhyman.com/pages/picks?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Sign Up for Dr. Hyman’s Weekly Longevity Journal https://drhyman.com/pages/longevity?utm_campaign=shownotes&utm_medium=banner&utm_source=podcast Join the 10-Day Detox to Reset Your Health https://drhyman.com/pages/10-day-detox Join the Hyman Hive for Expert Support and Real Results https://drhyman.com/pages/hyman-hive This episode is brought to you by Seed, Sunlighten, Function Health,Timeline, AirDoctor and Pique. Visit seed.com/hyman and use code 25HYMAN for 25% off your first month of Seed's DS-01® Daily Synbiotic. Visit sunlighten.com and save up to $1400 on your purchase with code HYMAN. Join today at FunctionHealth.com/Mark and use code HYMAN100 to get $100 toward your membership. Support essential mitochondrial health and save 10% on Mitopure. Visit timeline.com/drhyman to get 10% off today. Get cleaner air. Right now, you can get up to $300 off at airdoctorpro.com/drhyman. Receive 20% off FOR LIFE + a free Starter Kit with a rechargeable frother and glass beaker at Piquelife com/Hyman.
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  • The Nutrient Blueprint for a Longer, Healthier Life
    Nutrients are far more than supplements on a shelf—they are life-sustaining molecules that determine how well the body ages and resists disease. For years, their importance was overlooked because many studies were poorly designed, failing to consider existing nutrient levels or how vitamins and minerals work together. Strong evidence now shows multivitamins can slow brain aging, omega-3s can extend life expectancy, and shortages of vitamin D, magnesium, and B12 are widespread drivers of inflammation and chronic illness. Knowing and addressing individual deficiencies is critical, as these nutrients power billions of chemical reactions every second and are foundational to vitality and longevity. In this episode, I discuss, along with Dr. Rhonda Patrick and Steve Martocci, why nutrients are essential for a healthy body and how to choose the highest quality supplements. Dr. Rhonda Patrick is a scientist and health educator recognized for her leadership in aging and disease prevention. As the founder of FoundMyFitness, she provides evidence-based insights to a global audience through her website and podcast. On YouTube, she engages millions in in-depth discussions on evidence-based strategies for well-being. Dr. Patrick’s focus areas include genetic influences in dietary response, micronutrients, sleep, non-pharmacological approaches to mental well-being, and the surprising and paradoxical benefits of biological stressors such as exercise, heat, cold exposure, and plant phytochemicals. As an associate scientist and board member at the Fatty Acid Research Institute, she advances understanding of omega-3 fatty acids in aging and health. Her research has been published in high-impact journals like Nature Cell Biology, Experimental Gerontology, and FASEB. Steve Martocci is the co-founder and CEO of Suppco, a smart supplement tracking platform helping people take the right supplements with confidence. After years of struggling with his health and hitting 300 pounds, Steve turned to functional medicine and supplements to reclaim his well-being. That personal transformation—and the confusion he faced along the way—inspired him to build Suppco. Suppco helps users track what they’re taking, avoid unnecessary or low-quality products, and personalize their supplement routine with tools like brand TrustScores, protocol guides, and stack analysis. This episode is brought to you by BIOptimizers. Head to bioptimizers.com/hyman and use code HYMAN to save 15%. Full-length episodes can be found here: The Nutrient Gaps That Could Be Aging You Faster My Favorite Supplements for Optimal Health & Longevity How to Choose the Right Supplements (and Avoid the Wrong Ones)
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Über The Dr. Hyman Show

Welcome to The Dr. Hyman Show, the groundbreaking podcast redefining health in America and empowering you to take ownership of your health. Hosted by Dr. Mark Hyman—this show tackles the most pressing issues of our time: chronic disease, mental health, food policy and controversy, prevention and recovery, and longevity. In an era where our food system fuels disease and outdated healthcare models fail to address root causes, Dr. Hyman delivers evidence-based insights and expert interviews to help you become the CEO of your own health—something your doctor isn’t doing. The Dr. Hyman Show goes beyond the headlines to reimagine a food and healthcare system that protects health, unburdens our economy from the weight of chronic disease, supports the environment, and secures a vibrant future for all Americans. Whether you’re looking for cutting-edge protocols to transform your health, strategies to combat the chronic disease epidemic, or deep conversations about how wellness intersects with food, politics, and the environment, this podcast is your trusted guide. Rethink disease, claim your health, and join the movement for a healthier nation—tune into The Dr. Hyman Show today!
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