eanCast: Weekly Neurology

• Ep. 176: Embolic Stroke of Undetermined Source: Diagnostic Challenges and Therapeutic Options

  Moderator: Theodoros Mavridis (Dublin, Ireland) Guests: Diana Aguiar de Sousa (Lisbon, Portugal), Mira Katan (Basel, Switzerland) Embolic stroke of undetermined source (ESUS) continues to challenge clinicians as its definition and diagnostic approach evolve. In this episode, Theodoros Mavridis is joined by Diana Aguiar de Sousa and Mira Katan. They explore the epidemiological, clinical and mechanistic nuances of ESUS, discuss insights gained from major clinical trials, and examine current therapeutic strategies. The conversation also highlights advances in detecting covert embolic sources, the emerging relevance of atrial myopathy, the role of PFO closure, and the promise of biomarkers in shaping future patient care.

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• Ep. 175: Acute Ischemic Stroke: Evolving Guidelines and Clinical Decisions

  Theodoros Mavridis (Dublin, Ireland) Ana Catarina Fonseca (Lisbon, Portugal) In this episode, Theodoros Mavridis speaks with Ana Catarina Fonseca about the updated European guidelines for acute ischemic stroke. They discuss advances in reperfusion therapy, including extended time windows for thrombolysis using advanced imaging, broader eligibility criteria, and evidence supporting thrombectomy in patients with low ASPECTS scores, mild deficits, and posterior circulation strokes. The conversation also highlights the continued importance of stroke unit care and emerging pre-hospital technologies aimed at speeding diagnosis and improving outcomes.

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• Ep. 174: Breakthrough Stroke: Diagnostic and Therapeutic Dilemmas

  Moderator: Theodoros Mavridis (Dublin, Ireland) Guest: David Seiffge (Bern, Switzerland) In this episode, Theodoros Mavridis speaks with guest David Seiffge about breakthrough strokes, a challenging condition where ischemic strokes occur despite the use of antithrombotic therapies. They explore the diagnostic process, investigating compliance, and identifying competing etiologies. Prof. Seiffge also discusses potential treatment options, including emerging therapies like Factor 11 inhibitors and left atrial appendage closure, offering insights into ongoing trials aimed at improving patient outcomes.

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• Ep. 173: Acute Intracerebral Haemorrhage: Modern Management Strategies

  Moderator: Benedetta Storti (San Donà di Piave, Italy) Guest: Charlotte Cordonnier (Lille, France) Join Benedetta Storti and Charlotte Cordonnier for a discussion on the acute management of intracerebral hemorrhage. Discover the latest European Stroke Organization guidelines, the importance of timely intervention, and the evolving role of reversal agents and surgical approaches in stroke care.

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• Ep. 172: Brain health ambassadors: bridging advocacy and action into neurology

  Moderator: Mathilde Leonardi (Milan, Italy) Guests: Sanja Gluscevic (Podgorica, Montenegro), Simone Salemme (Modena, Italy) This episode explores how early-career neurologists can bridge science, policy, and society through advocacy—highlighting real examples of how EAN Brain Health Ambassadors are translating brain health into action both within and beyond clinical practice. Becoming a certified Brain Health Ambassador through the EAN's Advocacy Training programme offers neurologists the chance to advance brain health by gaining the knowledge and practical skills needed to advocate effectively at local, national, and European levels. As part of the training, participants will explore the principles of effective advocacy, develop communication strategies, and learn how to engage with key stakeholders such as policymakers and patient organizations in order to drive positive change.

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