Qualy #43 - What are Peter’s thoughts on fasting and ketosis for females?
Today's episode of The Qualys is from podcast
#75 - David Light: Zantac recall due to cancer concerns – what you need to know
In this episode, David Light, CEO of Valisure (the company which alerted the FDA to the Zantac cancer concerns), explains the story behind the recent recalls by manufacturers of ranitidine, a common heartburn medication, sold under the trade name Zantac, due to a potential link to increased cancer risk. David breaks down all the evidence, the role of his unique pharmacy company which tests all its drugs before being dispensed to consumers, and the reason behind the FDA’s tempered reaction to the alarming study results. David makes the argument that Zantac/ranitidine is an inherently unstable molecule which explains the grossly excessive amounts of NDMA (a probable human carcinogen) as opposed to just a contamination for which there could be numerous causes. Finally, David and Peter both provide recommendations for what to do if you or someone you know is currently taking Zantac/ranitidine. We discuss: The impetus for starting Valisure, a unique online pharmacy that tests all its medications [6:45]; The story behind the recall of valsartan, and the role which Valisure played [24:30]; Testing Zantac: The shocking results from Valisure’s initial testing with major potential cancer implications [36:00]; NDMA - the probable human carcinogen found in Zantac/ranitidine [48:45]; The epidemiology question: Are we inferring too much from epidemiology? What can we take away from the existing studies? [53:30]; The staggering results from the 2016 Stanford study, why it didn’t alarm more people, and how Valisure found the missing biological link [1:01:30]; Alerting the FDA, the FDA’s tempered response, and question of contamination vs. inherent instability [1:07:30]; How confident is David that the elevated levels of NDMA being found in ranitidine are not due to instrumentation, human error, or temperature contamination? [1:24:15]; The massive risk being taken by the FDA by not doing more to keep ranitidine away from consumers [1:25:15]; If someone is taking Zantac/ranitidine, what should they do? What else do they need to know? [1:27:45]; and More. Learn more: .
Qualy #38 - Finding meaning in struggle and why we are less happy than ever (David Foster Wallace)
Today's episode of The Qualys is from podcast
#74 – Jason Fried: Optimizing efficiency and work-life balance
In this episode, Jason Fried, co-founder of Basecamp, shares his beliefs around achieving business success in a modern world which tends to disproportionately focus on the massive success stories (the outliers). Jason gives his honest take on companies like WeWork, Uber, and Lyft that may give off the appearance of wild success but may instead provide an example of the dangers of perverse incentives. We get into Jason’s backstory, and how his affinity for optimizing efficiency and production in the workplace culminated with the creation of Basecamp, his very successful web-based project management software business. Perhaps most importantly, we get really deep into all aspects of work-life balance and what it really means to “work hard” (Stay tuned for an AMA-style deep dive into the topic of work-life balance with Jason in the near future). In addition, Jason provides many more valuable nuggets including thoughts on some common mistakes made by businesses today, the value of giving employees autonomy, how to take the right types of risks, why he doesn’t set any goals, and much, much more. We discuss: Jason’s background and his early entrepreneurial spirit [9:45]; Views on completing higher education and the notion of hard work [24:00]; Beliefs around success in business [35:00]; WeWork, Uber, and Lyft: Poor business practices and the dangers of perverse incentives [41:30]; Jason’s early career: his redesign approach and personal motivation [56:00]; The genesis of Basecamp [1:10:00]; Why Jason does not set goals but instead focuses on a vision [1:12:15]; Workplace motivation and hiring practice [1:20:30]; The importance of luck and not overworking [1:32:00]; A framework to work less and optimize for workplace autonomy [1:38:00]; The importance of saying ‘no’ more often (and tips for doing so) [1:55:00]; A shared passion for watches [2:03:30]; Guarding against the perils of phone addiction [2:08:45]; Jason’s views on email and chat for communication [2:15:00] and; More. Learn more: .
Qualy #33 - How silent bravado and incessant striving can lead to a functional (and actual) death, and why Paul is critical of the current state of psychiatry