Biohacking Beauty: The Anti-Aging Skincare Podcast

Hyaluronic acid has been the default answer to dry skin for years, which is why it shows up in serums, moisturizers, mists, and masks, often several on the same bathroom counter. But the claims that sold it, from holding 1,000 times its weight in water to working like a topical filler, have drifted a long way from what it actually does on your skin.
And some of the problems people blame on it, come from somewhere else. A serum that leaves skin tight by the afternoon usually has a formula problem, not an ingredient problem, and a lesser-known ingredient called ectoine has research showing hydration that holds for days after you stop applying it. So before you buy another hyaluronic acid product, it is worth knowing what it can and can't do, and what else deserves a place in your routine.
In this Biohacking Beauty Class, we break down hyaluronic acid vs. ectoine, from what each one actually does in the skin to why we've moved many of our formulas toward ectoine. We get into whether hyaluronic acid can make skin feel drier, why a topical serum can't work like filler, the truth about multi-weight hyaluronic acid, what ectoine research shows for eczema-prone skin, and what neither ingredient can do for aging skin.
What’s Discussed:
(03:18) Rapid fire: Is hyaluronic acid the next overrated skincare ingredient?
(08:17) What hyaluronic acid actually is, and why the "acid" doesn't mean exfoliant.
(15:51) What "holds 1,000 times its weight in water" really tells you.
(17:58) Why a topical hyaluronic acid serum can't work like an injectable filler.
(19:31) Can hyaluronic acid actually make your skin feel drier?
(20:42) The truth about multi-weight hyaluronic acid and "deeper penetration."
(27:13) What ectoine is and where it comes from.
(31:30) The research behind ectoine's longer-lasting hydration.
(35:24) What ectoine studies show for eczema-prone skin.
(36:32) Why ectoine quality varies so much from one supplier to the next.
(50:45) What neither hyaluronic acid nor ectoine can do for aging skin.
(54:58) What to do if you have five hyaluronic acid products on your counter.
Listen to this episode of Biohacking Beauty before you buy another serum just because hyaluronic acid is on the front of the bottle.
Products Mentioned:
BIO-SHIELD SPF 40
L.A.D.R. SERUM
BLUE PEPTIDE SPRAY
AMPLIFYING ESSENCE
Related Episodes:
The Mitochondria Problem Behind Aging Skin + How to Recharge Your Skin and Look Younger
The NAD+ Thief Your Skin Can't Escape: CD38, Zombie Cells, and the Decline

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Find more from Young Goose:
Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

Most people treat hair, scalp, and skin as three separate problems, each with its own shelf of products. But all three are built from keratin and run on the same growth signals, so thinning hair can say as much about how you're aging as a new wrinkle.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Amy Spizuoco. We also chat about what's really behind Ozempic hair loss, which hair loss treatments hold up in the evidence, and the popular hair supplement she calls the biggest waste of money.
Dr. Amy Spizuoco, DO, FAOCD, FAAD, is a board-certified dermatologist and dermatopathologist and the founder of True Dermatology in New York City. She is a Clinical Instructor of Dermatology at the Icahn School of Medicine at Mount Sinai, past president of the American Osteopathic College of Dermatology, and serves on the editorial boards of Practical Dermatology and Dermatology Times. She is also co-founder and co-chair of the DermVIP Summit, a dermatology conference dedicated to hair loss and scalp conditions.
What’s Discussed:
(01:25) Why hair, scalp, and skin are more connected than three product shelves suggest.
(04:14) How collagen 17 links thinning hair and thinning skin.
(07:17) Why the future of collagen is protecting what you have, not just rebuilding it.
(10:09) What gray hair and cell senescence reveal about aging in the rest of the body.
(15:26) When to start scalp care, and the scalp symptoms that need attention right away.
(20:33) How the hair growth cycle shortens as you age.
(29:31) What's really behind Ozempic hair loss, and what to put in place before starting a GLP-1.
(37:17) PRP, red light caps, and exosomes: which hair loss treatments actually hold up.
(45:46) The truth behind retinoid "thinning" and finasteride side effects.
(49:54) The hairline changes that mean you should see a dermatologist now.
(53:16) The hair supplement Dr. Amy calls the biggest waste of money.
Listen to this episode of Biohacking Beauty before you spend another dollar on biotin, scalp serums, or rosemary oil.
Resources Mentioned:
Xtressé Nutrient Hair Growth Gummies: shop.advancedderm.com

Related Episodes:
Dr. Alan Bauman: Why Biohackers Are Losing Their Hair Faster Than Everyone Else
Q&A: Your Questions Answered on Exosome Skincare (Everything You Need to Know Before You Try)

Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare

Find more from Dr. Amy Spizuoco & True Dematology:
Website: true-dermatology.com
Instagram: @drspizderm

In your 40s, skin can suddenly turn red, itchy, flaky, or reactive, sometimes in random places, and most women assume it is just aging or blame their skincare. But the estrogen and progesterone shifts of perimenopause can change how mast cells release histamine at the skin barrier, which means the trigger may be happening inside the body, not inside the bottle.
We dive deeper into this in the Biohacking Beauty Podcast with Dr. Carrie Jones. We also chat about why a retinoid you have used for years can suddenly irritate your skin, why wine hits so differently in your 40s, and the overlooked lab that could explain hair loss and fatigue.
Dr. Carrie Jones, ND, FABNE, MPH, MSCP, is a naturopathic physician who completed a two-year residency in women's health and endocrinology, is board certified through the American Board of Naturopathic Endocrinology, and is a Menopause Society Certified Practitioner. She was the first medical director for Precision Analytical (the DUTCH Test) and the first head of medical education at Rupa Health. She has more than 20 years of experience in women's health and hormones and hosts the Hello Hormones podcast.
What’s Discussed:
(00:21) Why skin can suddenly turn red, itchy, and reactive in your 40s.
(02:20) Why a retinoid you have used for years can start irritating your skin in perimenopause.
(06:00) How mast cells and histamine create redness, welts, and itching that seem random.
(09:43) How bone broth and fermented foods can add to an already full histamine bucket.
(12:01) Why wine affects your liver, hormones, and skin differently in perimenopause.
(16:59) Alcohol-free ways to wind down at night, from holy basil tea to magnesium.
(20:50) What it means if an antihistamine before bed helps you wake up feeling better.
(23:28) Why progesterone is often the first hormone to drop and how that affects mast cells.
(27:46) The overlooked histamine trigger that can worsen PMS and skin, plus the biggest lever of all.
(35:01) Why ferritin belongs on your blood work, how low is too low, and when supplements are not enough.
(43:27) What to ask your doctor for, so you leave with more than another cortisone cream.
(48:27) Rapid fire: estrogen dominance, seed cycling, red wine, and the one thing every woman over 40 should stop doing.
Listen to this episode of Biohacking Beauty before you blame your next flare on aging or your skincare routine.
Resources Mentioned:
Mira Hormone Monitor: miracare.com
Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off at younggoose.com
Instagram: @young_goose_skincare
Find more from Dr. Carrie Jones:
Website: drcarriejones.com
Instagram: @dr.carriejones
YouTube: Dr. Carrie Jones
Podcast: Hello Hormones with Dr. Carrie Jones

Most skincare routines are built by accumulation: a serum that went viral, a cream a friend swore by, whatever promised firmer skin that month. But what drives skin aging at 25 is not what drives it at 45, so a routine that never changes its priorities can spend years working on the wrong problem.
And your birthday is only part of the picture. Some people's skin is running a decade ahead of their age, perimenopause can change what skin needs years before the 40s arrive, and the routine you will actually stick with is usually shorter than the one you think you need. So before you add another product, it is worth knowing what changes in your skin from one decade to the next and what each stage should prioritize.
In this Biohacking Beauty Class, we walk through a skincare protocol for every decade, from protection in your 20s to correction in your 30s and recovery in your 40s, 50s, and beyond. We get into the research tying sun exposure to 80% of visible facial aging, why NAD+ declines in aging skin, what makes many exosome formulas questionable, how to tell if your skin is aging ahead of your age, and the red light specs that actually matter.
What’s Discussed:
(02:17) Why your skin's age matters more than the number on your birthday.
(03:09) The "attention budget" and why a shorter routine often gets better results.
(04:44) The research linking sun exposure to 80% of visible facial aging.
(06:20) What happened when adults used sunscreen every day for four and a half years.
(12:06) Why NAD+ declines in aging skin and what changes after 30.
(15:03) How spermidine and autophagy help skin clear out what has expired.
(22:08) Why exosomes cannot survive alongside vitamin C, acids, and peptides in the same formula.
(24:04) The part of aging in your 40s that sunscreen cannot fully cover.
(26:10) Why perimenopause and menopause mean moving up a stage, whatever your age.
(31:22) A first look at the Youth Activating Ampoule and why some actives have to stay freeze-dried.
(42:05) What to use at home in the weeks around microneedling and laser treatments.
(45:25) What the research says about red light therapy and the specs worth paying for.
(51:53) How to find out if your skin is aging ahead of your age.
Listen to this episode of Biohacking Beauty before you add another product to your routine, so you know what your skin needs at the stage it is actually in.
Resources Mentioned:
Skincare by Age protocol: https://www.younggoose.com/pages/science
Decade-by-Decade Skincare Field Guide
Young Goose AI Facial Scanner
SkinOS™ Longevity Test
Find a Young Goose Professional
Previous Episodes Mentioned:
Anastasia and Amitay with Dave Asprey on The Human Upgrade
Find more from Young Goose:
Website: Use code PODCAST10 to get 10% OFF your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% OFF at younggoose.com
Instagram: @young_goose_skincare

There is an interesting contradiction in the way we talk about aging. We celebrate using technology to improve sleep, metabolism, cognition, recovery, and longevity, but when the same mindset is applied to appearance, the conversation can suddenly become much more judgmental.
In this episode of Biohacking Beauty, we sit down with Dave Asprey to explore that tension. We get into why he chose a facelift after major weight loss, whether cosmetic procedures belong in the biohacking conversation, and why wanting to look younger is often treated differently from wanting the rest of your body to function younger.
Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, CEO of Upgrade Labs, host of The Human Upgrade, and co-founder of Unlimited Life. We also talk about how he prepares his body before procedures, what he thinks people misunderstand about peptides, and his takes on GLP face, collagen supplements, Botox, stem cells, and the other tools people are using to change how they age.
What’s Discussed:
[13:02] Why Dave ultimately chose a facelift after major weight loss.
[15:24] Where non-surgical skin treatments reached their limit for the amount of excess skin he wanted to address.
[18:58] Why copying someone else’s longevity or supplement stack can backfire.
[28:59] Where to start when your biological-age markers look good but you still do not like what you see in the mirror.
[30:07] Why sleep, recovery, HRV, and other foundational markers still matter when thinking about aging.
[37:52] The stigma around cosmetic procedures in biohacking and why Dave questions where that line is drawn.
[44:56] Why he believes fear around aging and medical procedures can affect the body’s stress response.
[54:25] GLP-1s, muscle loss, and the changes people notice in facial appearance after weight loss.
Listen to this episode of Biohacking Beauty for a conversation about where “aging naturally” ends, where biohacking begins, and why that line becomes much more complicated when appearance enters the picture.

Find more from Young Goose:
Use code PODCAST10 to get 10% off your first purchase, and if you’re a returning customer use the code PODCAST5 to get 5% off atyounggoose.com
Instagram: @young_goose_skincare

Find more from Dave Asprey:
Website:daveasprey.com
LinkedIn: Asprey
Instagram:@dave.asprey
Facebook: Daveaspreyofficial
YouTube: DaveAspreyBPR
TikTok: @daveaspreyofficial
Book: “Heavily Meditated”: https://daveasprey.com/heavily-meditated/