All Things Urticaria – Learning about urticaria with Prof. Dr. Torsten Zuberbier

• Episode 106 – Urticaria Tracking with CRUSE: A Game-Changer for Patients & Research

  In this episode, Prof. Dr. Torsten Zuberbier (GA²LEN) welcomes Dr. Sophia Neisinger to discuss CRUSE, a digital health tool for chronic spontaneous urticaria (CSU). CRUSE is a free, globally available self-evaluation app that helps patients track their symptoms and provides valuable research data to improve urticaria care. They discuss:  📊 How CRUSE helps patients track their CSU symptoms daily.  🔬 How anonymized CRUSE data is shaping global urticaria research.  📢 The importance of continuous data input—even on good days.  💊 Treatment disparities worldwide & the fight against long-term corticosteroid use.  📡 Upcoming developments, including smartwatch & wearable integration. Join us as we explore how CRUSE is making a difference for patients, physicians, and researchers worldwide!  Key Learnings from the Episode:CRUSE is a free, validated self-evaluation app for CSU patients, helping track their disease and treatment effectiveness. Daily symptom tracking is crucial, even when patients feel well, to improve research insights. CRUSE data reveals treatment disparities worldwide, with some countries lacking access to second-line treatments. Systemic corticosteroids are still overused, despite their severe side effects, highlighting the need for better awareness and alternative treatments. CRUSE allows patients to share their symptom data with their physicians, improving personalized treatment decisions. The app is continuously evolving, with new features like improved reports and future integration with smartwatches and wearables. CRUSE is expanding globally, with North Macedonia being the next country to adopt the platform. Physicians and researchers can use CRUSE for studies, making it a valuable tool for small-scale trials and real-world data collection. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.Feedback form:ATU: ⁠⁠https://forms.office.com/e/m6a2uEdsUH

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• Episode 105 – Decoding Urticaria: Mast Cells, Triggers & Immune cell crosstalk

  In this episode, Prof. Torsten Zuberbier (Charité Berlin, GA²LEN) welcomes Dr. Stefan Frischbutter, senior researcher at the Institute of Allergy in Berlin, to explore the fascinating world of mast cells and urticaria. They discuss: 🔬 The critical role of mast cells in immune responses and skin conditions like urticaria. 💡 How temperature, autoantibodies, and nerves can trigger mast cell activation. 🦠 Different types of mast cell activation: IgE, IgG autoantibodies & pseudo-allergens. 🧪 New research techniques to study mast cells and identify better treatments. 💊 How eosinophils, neutrophils & T-cells influence chronic urticaria severity. 📢 The latest advances in urticaria treatment and why biopsies could guide therapy. Join us for an insightful discussion on the immune system’s “orchestrators” and how scientific discoveries are shaping the future of urticaria treatment! Key Learnings from the  epsiode:Mast cells act as immune response directors, responding to heat, cold, allergens, stress, and autoantibodies. Urticaria has multiple causes, including IgE and IgG autoantibodies, pseudo-allergen receptors (MRGPRX2), and nerve signals. Not all urticaria cases are histamine-driven—other immune cells like eosinophils and neutrophils play a major role. Chronic spontaneous urticaria patients often have autoantibodies targeting mast cells, making treatment challenging. Taking a skin biopsy at the right time (after a wheal disappears) can reveal immune cell involvement and guide personalized treatments. New research techniques, like mast cell activation tests and ex-vivo skin models, help identify triggers and potential treatments. Different immune cells require different treatments, and eosinophil/neutrophil-driven urticaria may need specialized drugs. Exciting future treatments are emerging, and ongoing research will provide better-targeted therapies for urticaria patients. Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.Feedback form:ATU: ⁠https://forms.office.com/e/m6a2uEdsUH

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• Episode 104 – Insights from the Global Urticaria Forum (GUF)

  Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.Feedback form ATU: https://forms.office.com/e/m6a2uEdsUH

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• Episode 103 - Solar urticaria

  What steps can be taken to manage solar urticaria? Professor Torsten Zuberbier and Dr Lea Kiefer examine solar urticaria, discussing the role of skin type, management strategies, and treatment methods.Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.Feedback form ATU: https://forms.office.com/e/m6a2uEdsUH

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• Episode 102 - Understanding urticaria: What you need to know

  Professor Torsten Zuberbier welcomes Dr Luis Ensina to discuss essential information for people with urticaria, highlighting the benefits of keeping a diary before medical appointments and how using patient-reported outcome tools can help doctors understand their condition better.Do you have suggestions for future episodes? Please provide feedback and offer your suggestions for future topics and expert selection here.Feedback form ATU: https://forms.office.com/e/m6a2uEdsUH

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