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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks : 1372
    Most people think you need sweat, strain, or long workouts to upgrade circulation, metabolism, and energy. What if your body could unlock all of that while you stand still? This episode reveals how to get a full body workout by doing absolutely nothing, and why a few minutes of targeted vibration can activate nitric oxide, improve microcirculation, calm your nervous system, and relieve the hidden damage from sitting all day. Host Dave Asprey shows you why the simplest biohack in the room might be the most powerful one you are not using. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Tommy Rhee, DC, a board-certified chiropractor known for his innovative approach to sports medicine and regenerative therapy. Dr. Rhee has treated professional athletes, starting NFL quarterbacks, and everyday people who want better mobility and faster recovery. He served as the official team chiropractor for the Tampa Bay Buccaneers and worked with multiple UCLA athletic programs. He also created RheeGen, a patent-pending topical transdermal stem cell cream that introduces a non-invasive path to tissue repair and pain relief. His book, The Future of Regenerative Medicine, outlines how topical stem cell treatments can transform performance and healing. Dr. Rhee’s background as a U.S. Navy aircrew member aboard S-3 Viking jets gives him a precision-driven understanding of human performance, resilience, and stress adaptation. In this episode, Dr. Rhee explains why whole body vibration works as a cheat code for circulation, fascia mobility, balance, mood, and nitric oxide activation. He shows how vibration increases microcirculation in places your workouts never reach, why it boosts lymphatic flow better than walking, and how it sends rapid-fire sensory signals that improve proprioception and stress recovery. You also learn why older adults benefit even more from this simple tool, how athletes use it as a warmup to conserve energy, and why three plane vibration dramatically outperforms cheap two dimensional devices. Dave and Dr. Rhee show you how to pair vibration with fasting, ketosis, nootropics, supplements, Danger Coffee, and Smarter Not Harder style training for maximum biohacking efficiency. You’ll Learn: • How to mimic the benefits of a full workout while standing still • Why nitric oxide drives circulation, longevity, and metabolic health • How vibration accelerates lymphatic drainage and clears stagnation • Why whole body vibration improves balance, sensory speed, and neuroplasticity • How athletes warm up with vibration to protect energy reserves • Why triplanar vibration beats two dimensional devices for real results • How vibration supports pelvic floor strength and erectile function • How to use vibration for joint protection, fascia mobility, and mitochondrial activation • The daily protocol Dr. Rhee uses for stress relief, mood, and brain optimization Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibration plate benefits, power plate workout, whole body vibration therapy, nitric oxide boost naturally, improve circulation fast, lymphatic drainage at home, fix leg swelling quickly, better than walking workout, passive exercise machine, joint friendly fitness, biohacking circulation hack, vibration plate for balance, how to increase microcirculation, proprioception training at home, vibration plate for seniors, rebounder vs vibration plate, fix poor circulation in legs, vibration therapy recovery, power plate warmup routine, best vibration plate for home use **Discount on your next Power Plate: https://powerplate.com/biohack ** Resources: • Power Plate Website: https://powerplate.com/biohack • Dr. Tommy Rhee’s Website: https://rheegen.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction: Whole Body Vibration 2:12 - Biological Activation Explained 4:05 - Nitric Oxide and Circulation 5:57 - Power Plate vs Walking 8:19 - Shearing Force and Fascia 11:25 - Planking and Exercise Variations 13:31 - Common Mistakes 15:03 - Microcirculation and Lymphatics 19:02 - Benefits for Young Athletes 22:15 - Types of Vibration Machines 25:21 - Proprioception and Balance 27:08 - Pro Athletes and Warm-Up 34:08 - Benefits for Women 35:35 - Benefits for Men 36:13 - Mood and Stress Relief 37:21 - Power Plate Deal and Recommendations 38:53 - Frequency Settings 40:58 - Power Plate vs Rebounder 44:03 - Usage for Ill or Elderly 46:53 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • How to Stop Brain Fog After Anesthesia | Biohacker Tips : 1370
    Prepare to rethink surgery, healing, anesthesia, and recovery. This episode gives you a complete, high-performance playbook for surgical preparation and accelerated healing, built on biohacking, functional medicine, neuroprotection, and mitochondrial resilience. You will learn how to recover up to three times faster, protect your brain from anesthesia related inflammation, and enter any procedure with the stability and metabolic readiness of an elite performer. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Cameron Chesnut, a facial plastic surgeon trusted by the world’s high performers. Patients travel from every corner of the globe for his minimally invasive results that look natural, rejuvenated, and untouched. He is known for progressive regenerative medicine techniques, brain safe anesthesia protocols, advanced postoperative recovery strategies, and a personal commitment to performance readiness that mirrors the mindset of elite athletes. His methods bridge functional medicine, metabolism, supplements, sleep optimization, nootropics, and regenerative science to transform the entire surgical experience. Together, they reveal how to avoid the hidden pitfalls that create postoperative brain fog, inflammation, mitochondrial dysfunction, and slow recovery. You learn how to work with your anesthesiologist, avoid harmful drug combinations, and stack ketones, fasting, NAD, glutathione, stem cell rich fat grafts, IV therapy, and hyperbarics for rapid healing. Dr. Chesnut explains why fillers migrate, why general anesthesia often disrupts cognition, how exogenous ketones stabilize neurons, and how regenerative peptides, ketosis, circadian timing, and nutritional density shift the biology of recovery. You’ll Learn: • How Host Dave Asprey prepares his brain and mitochondria before anesthesia • Why standard anesthesia protocols increase neuroinflammation and cognitive dysfunction • How to use ketamine and dexmedetomidine instead of benzos, opiates, and amnesia drugs • Why fillers migrate and how regenerative fat grafting outperforms traditional filler • How exogenous ketones enhance neuronal stability during anesthesia • Why hyperbarics, red light, PEMF, and IV therapy shorten recovery time • How peptides like BPC, GHK copper, and TB4 support tissue repair • Why metabolic health, carnivore leaning nutrition, and real protein accelerate healing• How nicotine influences angiogenesis and when it can help • The real difference between healing fast and healing well • How to structure your recovery environment for sleep optimization and better outcomes • Why elite performers treat surgery like an athletic event and prepare the same way • How to talk to your surgical team so your biology stays protected and optimized Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: Regenerative surgery optimization, anesthesia brain protection, postoperative cognitive dysfunction, accelerated surgical healing, functional medicine surgery prep, ketamine conscious sedation, dexmedetomidine anesthesia protocol, mitochondrial recovery support, stem cell rich fat grafting, surgical hyperbaric therapy, exogenous ketone neuroprotection, fasting preparation, nootropic assisted recovery, peptide tissue repair, filler migration correction, angiogenesis enhancement, circadian prep, sleep optimized anesthesia, metabolic healing strategy, nicotine angiogenesis Thank you to our sponsors! -Essentia | Go to https://myessentia.com/dave and use code DAVE for $100 off The Dave Asprey Upgrade. -ECHO Water | Go to http://echowater.com/dave and use code DAVE10 for 10% off your ECHO Flask. -ARMRA | Go to https://tryarmra.com/ and use the code DAVE to get 15% off your first order. -Caldera + Lab | Go to https://calderalab.com/DAVE and use code DAVE at checkout for 20% off your first order. Resources: • Cameron’s Clinic: https://www.clinic5c.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 2:05 - Pre-Surgery Optimization 5:41 - Stem Cells and Fat Transfer 9:28 - Brain Safe Anesthesia 15:43 - Propofol Alternatives 21:06 - Non-Opioid Pain Control 27:22 - Recovery Protocols 29:11 - Xenon Gas Insights 31:02 - Racetams and Brain Protection 33:18 - IV Glutathione 43:24 - Ketones for Surgery 44:06 - Growth Hormone and Peptides 55:57 - Nicotine and Healing 58:37 - Surgical Lighting 1:05:23 - Filler Migration 1:15:18 - Final Takeaways See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Why Breathwork Feels Like a Euphoric Drug | Biohacker Tips : 1369
    Breathwork is one of the most powerful tools in biohacking, yet most people only experience the surface level techniques. When you use it the right way, breathwork can upgrade your brain, strengthen your nervous system, improve sleep, and open awareness states that amplify longevity and human performance. This episode features Ishan Shivanand, a globally celebrated yogic scholar, mental health researcher, and bestselling author who was raised in the monasteries of India under Mahasiddha Avdhoot Shivanand. He carries one of the world’s oldest Shiv Yogi lineages and created the clinically validated Yoga of Immortals method, which has helped millions reverse anxiety, depression, insomnia, burnout, and trauma. Together, Host Dave Asprey and Ishan reveal how lineage level breath practices shape consciousness, neuroplasticity, and emotional resilience. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey and Ishan explore the full arc of ancient yogic training, from how breathwork directs prana through the body to how chanting alters brain states, emotional regulation, and nervous system function. They break down the role of visualization in building neuroplasticity, the symbolism and physics of sacred sound, and the science of moving awareness through the spine. The conversation moves into rarely discussed topics including the yogic art of choosing one’s death, how advanced practitioners leave the body, the meaning of immortality in spiritual traditions, and how dharma shapes whether long life becomes a blessing or a burden. You will hear how ancient monks trained through martial arts, mantra repetition, sacred geometry, gold symbolism, alchemy, and the cultivation of higher states of consciousness, and how these practices compare to modern biohacking tools like fasting, ketosis, nootropics, supplements, sleep optimization, functional medicine, and mitochondrial support. This episode shows you how Eastern mystical training and Western performance science intersect and how these teachings fit naturally within the Smarter Not Harder framework. This conversation also covers plant medicine, psychedelics, and the difference between ancient ceremonial use and modern recreational misuse. You will hear how lineage based training uses breath, awareness, and mantra to alter redox balance, regulate the autonomic nervous system, strengthen energy production, and shape brain optimization at the deepest levels. You’ll Learn: • Why breathwork changes brain states faster than basic meditation and how it drives neuroplasticity • How chanting affects the vagus nerve, emotional regulation, and nervous system balance • How visualization strengthens nerve pathways, trauma resolution, and sleep optimization • The meaning behind sacred sound, vibration, and the origins of consciousness in ancient lineage training • Why monks train with martial arts, mantra repetition, and sacred geometry to enhance awareness • How yogic philosophy approaches immortality, choosing one’s death, and leaving the body consciously • Why dharma shapes whether long life becomes a blessing or a curse • How plant medicine differs when used ceremonially versus recreationally • How to integrate these teachings into your own longevity, performance, and human potential strategy Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: advanced breathwork techniques, prana movement training, mantra induced trance states, sacred sound vibration science, visualization neuroplasticity practice, yogic spinal awareness training, autonomic nervous system regulation, ancient Himalayan lineage meditation, art of conscious death practice, yogic immortality teachings, dharma based longevity strategy, astral body leaving techniques, yogic alchemy and transformation, sacred geometry meditation, pranic channel activation, ceremonial plant medicine use, trauma release breathwork, nervous system coherence chanting, biohacking consciousness optimization, mitochondrial and prana synergy Thank you to our sponsors! -Generation Lab | Go to http://generationlab.com/, use code Dave20 for $20 off, and see what your body’s really doing behind the surface. -Our Place | Head to https://fromourplace.com/ and use the code DAVE for 10% off your order. -BodyHealth | Go to https://bodyhealth.com/ and use code DAVE20 to save 20% off your first order of PerfectAmino. Resources: • Ishan’s Website: https://ishanshivanand.com/ • Ishan’s Book ‘The Practice of Immortality’ : https://practiceofimmortality.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Trailer 1:25 — Meditation Training 4:12 — Chanting and Mantras 8:09 — Jesus in India 10:50 — Coffee and Consciousness 14:54 — Unity of Religions 19:57 — Visualization Practice 22:57 — Gold Symbolism 26:01 — Alchemy and Transformation 28:45 — Psychedelics as Medicine 31:42 — Technology and States 37:43 — Choosing Death 39:12 — Death and Consciousness 43:31 — Dharma and Immortality 45:18 — Art of Dying 51:00 — Longevity and Meditation See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Dead Water Is Making You Sick! (Biohacking Bonus Episode) : 1368
    Here’s the hidden story behind why you can chug “pure” water all day and still feel foggy, drained, and oddly thirsty: most of what we drink is missing something essential. In this video you’ll learn what “dead water” really is, how to tell if yours is part of the problem, and the simple shifts that keep your brain sharp, energy steady, and cells fully charged—without gimmicks, hype, or drinking a gallon a day.Chapters:00:00 – The “dead water” problem00:23 – Why minerals matter for your brain, heart & energy01:07 – 5,000 hydration scans: what the data shows01:33 – The 8-glasses myth (and who benefited)03:11 – Bottled water marketing vs reality04:17 – Tap water: safe ≠ complete06:00 – Hyponatremia: when “more water” backfires07:05 – Electrolytes your cells run on07:56 – What to do: filters, mineralizing, simple add-ins09:03 – Timing hydration + daily micro-habitsConnect with Dave Asprey!Thank you to our sponsors! -LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser.-Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave.Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: https://www.instagram.com/TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/Danger Coffee: https://dangercoffee.com/DAVE15Dave Asprey’s BEYOND Conference: https://beyondconference.com/Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15Upgrade Collective: https://www.ourupgradecollective.comUpgrade Labs: https://upgradelabs.com40 Years of Zen: https://40yearsofzen.comSee Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • 10-Minute Biohacking News Update : 1367
    This episode covers: • Nano CBD Pain Relief Without Cognitive Side Effects A new nano-micelle formulation of CBD called CBD-IN delivers fast, non-addictive pain relief in mice without memory issues, motor impairment or the usual cannabinoid “fog.” Because it crosses the blood brain barrier and directly targets hyperactive pain circuits, it sidesteps many opioid-type drawbacks. Dave explains why precision-designed cannabinoids could reshape chronic pain treatment and longevity support. Source: https://www.sciencedaily.com/releases/2025/11/251117095652.htm • Moderate Calorie Restriction Slows Biological Aging A long-term trial from the National Institute on Aging found that cutting calories by about 12% over two years slowed the pace of aging — measured by methylation clocks and metabolic markers — in lean and mildly overweight adults alike. Dave breaks down why small, manageable dietary tweaks can deliver big longevity gains, without crash dieting or extreme fasting. Source: https://www.nia.nih.gov/news/cutting-calories-may-slow-pace-aging-healthy-adults • FDA Approves AI-Guided Robotic Surgery Trials for Alzheimer’s The U.S. Food and Drug Administration (FDA) has granted IDE approval for the first robotic microsurgical study targeting early stage Alzheimer’s disease using AI and deep imaging. The trial uses adaptive robotics to target deep brain lymphatic pathways, potentially clearing amyloid/tau deposits with surgical precision. Dave explains why this signals a new era in neurodegeneration – moving from drug-only to machine-assisted brain repair. Source: https://www.mmimicro.com/ide-approval-for-first-robotic-microsurgery-alzheimers-study/ • Antibiotic Reprograms Gut Bacteria to Produce Anti-Aging Molecules Researchers demonstrated that the veterinary antibiotic cephaloridine can reprogram gut microbes to secrete colanic acid — a molecule linked to better mitochondrial health, reduced gut permeability and improved cholesterol/insulin balance in mice. Dave explores how this could evolve into a pipeline of engineered probiotics that act as internal “longevity factories.” Source: https://newatlas.com/aging/antibiotic-longevity-microbiome/ (link remains unchanged) • Klotho: The Longevity Protein Nears Clinical Reality The longevity protein Klotho, known for clearing toxic by-products, calming inflammation and protecting brain/organ networks, is now advancing toward human trials via injectables, oral formats and gene therapy. Dave explains why Klotho is shaping up as a foundational target for next-gen age-reversal strategies and stacking protocols. Source: https://investingnews.com/longevity-focused-health-fueling-u-s-anti-aging-products-market-projected-to-reach-27-billion-by-2033/ (link remains unchanged) All source links provided for easy reference to the original reporting and research above. This episode is essential listening for fans of biohacking, human performance, functional medicine and longevity who want practical tools from Host ­Dave Asprey and the latest breakthroughs shaping the future of health. Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade gives you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence and conscious living. New episodes are released every Tuesday, Thursday, Friday (audio only) and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: nano CBD, CBD-IN, pain relief research, non opioid pain therapies, chronic pain and aging, caloric restriction aging, methylation clocks, metabolic resilience, AI robotics, Alzheimer’s microsurgery, neurotech advancement, microbiome engineering, colanic acid, longevity probiotics, mitochondrial support, Klotho protein, anti aging gene therapy, cellular rejuvenation, longevity news, biohacking updates Thank you to our sponsors! LYMA | Go to https://lyma.sjv.io/gOQ545 and use code DAVE10 for 10% off the LYMA Laser. Vibrant Blue Oils | Grab a full-size bottle for over 50% off at https://vibrantblueoils.com/dave. Resources: • Subscribe to my weekly newsletter: https://substack.daveasprey.com/welcome • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 — Intro 0:19 — Story 1: Nano CBD for Pain Relief 1:53 — Story 2: Caloric Restriction and Aging 3:20 — Story 3: AI Robotic Surgery for Alzheimer’s 4:50 — Story 4: Microbiome Reprogramming 6:05 — Substack Announcement 7:04 — Story 5: Klotho Longevity Protein 8:39 — Weekly Homework 9:31 — Outro See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Über The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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