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The Human Upgrade: Biohacking for Longevity & Performance

Dave Asprey
The Human Upgrade: Biohacking for Longevity & Performance
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  • The Real Reason Your Face Is Aging So Fast : 1376
    Vitamin C, copper peptides, and glutathione behave very differently once you understand how skin absorbs nutrients at the cellular level. This episode shows you how to target collagen production, strengthen mitochondria, improve detox capacity, and upgrade skin density with pharmaceutical grade delivery systems that outperform conventional skincare. You learn why most topical antioxidants never reach their intended targets, how intracellular copper changes longevity pathways, why glutathione affects everything from pigmentation to detox, and how to build a streamlined routine that matches the way high level biohackers actually age. These strategies can help you improve collagen, elasticity, hair density, mitochondrial function, and whole body performance with fewer steps and far more impact. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey talks with Dr. Nayan Patel, a pharmacist, wellness expert, and industry leader who has worked with physicians since 1999 to design custom medications and patient specific protocols. He has been the pharmacist of choice for celebrities, CEOs, and medical professionals seeking precision level formulations. Dr. Patel is the author of The Glutathione Revolution, which summarizes more than a decade of clinical research on glutathione. His team created a patented transdermal technology that delivers glutathione systemically through the skin, and he has since expanded this work to include advanced peptides and new delivery systems that improve absorption far beyond standard topical products. He also developed the Auro GSH Antioxidant Delivery System, a skincare line that uses pharmaceutical grade ingredients at potent concentrations to achieve deeper penetration and more reliable biological effects. Together they break down why vitamin C acts as a stimulant that drives collagen rather than a classic antioxidant, how GHK copper peptide thickens aging skin, and why retinoids often speed up cell turnover at the cost of long term resilience. Dr. Patel explains the difference between cosmetic grade and injectable grade peptides, why purity matters when a delivery system pushes molecules deep into the skin, and how zinc overuse has created widespread copper deficiency that affects hair, metabolism, and mitochondrial health. Dave shares his own protocols for using GHK, glutathione, and vitamin C, along with practical dosing strategies that create visible changes in skin density within four to six weeks. You will learn: • How vitamin C stimulates collagen and why glutathione regenerates oxidized antioxidants • How GHK copper peptide improves elasticity, firmness, and structural integrity • Why purity, molecular size, and delivery tech determine whether peptides actually reach target tissues • How topical copper supports intracellular stores and influences hair health and metabolism • Why zinc overload causes silent copper deficiency and what it means for longevity • How targeted glutathione improves detox, pigmentation, and oxidative stress • The fastest protocol for visible skin density improvements and how long results take to show • How to combine these tools with lasers and skin procedures for stronger outcomes Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: GHK copper peptide, topical glutathione delivery, dextrin absorption technology, intracellular copper uptake, vitamin C collagen stimulation, antioxidant regeneration, cosmetic peptide purity, injectable grade peptides, zinc copper imbalance, mitochondrial skin health, hair follicle regeneration, oxidative stress reduction, glutathione detox support, peptide based skincare, collagen crosslinking support, DMAE skin firmness, CoQ10 topical benefits, skincare biohacking, longevity dermatology, pharmaceutical transdermal systems Resources: • Go to https://aurowellness.com/ ‘DAVE10’ for a discount! • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - Introduction 5:51 - Delivery Technology and How It Works 9:34 - Product Development and Formulations 21:29 - Application and Usage Guidelines 32:17 - Hair Growth and Specific Concerns 37:22 - Copper, Deficiency and Body Systems 40:52 - Special Topics and Protocols 52:00 - Dosing Protocols and Closing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Feel 70 Percent Better… With Grapes? | Biohacking Tools : 1374
    If you care about longevity, mitochondria, cardiovascular health, or feeling sharper every day, this episode gives you a clear look at the breakthrough technology that could reshape how supplements are made. Host Dave Asprey talks with Ilan Sobel, CEO of BioHarvest Sciences, about a new way to produce plant compounds at industrial scale without ever growing the plant. Their Botanical Synthesis platform creates highly pure, clinically validated molecules that support blood flow, brain function, metabolic health, and cellular energy with remarkable consistency and little to no environmental waste. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Ilan brings more than two decades of experience in global biotech and consumer health, and under his leadership BioHarvest has grown its flagship product VINIA into one of the fastest growing plant-based supplements in North America. He explains how the company uses plant cell biology and AI guided cultivation to deliver resveratrol, polyphenols, and other high value compounds with superior bioavailability, purity, and measurable clinical effects on arterial dilation, driven by increasing nitric oxide and resulting in improving physical energy, mental alertness and reducing oxidative stress You will learn: • Why traditional extraction wastes most of the plant and creates inconsistent supplement quality • How Botanical Synthesis produces highly bioavailable polyphenols without insecticides, herbacides, fungicides, solvents, or worrying about heavy metal levels.• Why VINIA increases arterial dilation, improves blood flow, and supports healthy nitric oxide levels • How reducing ET1 strengthens vascular health in ways typical nitric oxide supplements cannot • Why better blood flow supports brain performance, mental alertness, and daily physical energy • What clinical studies show about resveratrol absorption, bioavailability, and 12 hour activity in the bloodstream • How piceid resveratrol crosses the blood brain barrier to support cognitive function • Why BioHarvest is developing olive cell compounds like verbascoside for liver fat reduction and cognitive aging • How future saffron cell technology may influence mood, stress, and cognitive health • Why this approach offers major advantages for longevity, anti-aging strategies, and high-performance biologyDave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: plant cell biology, Botanical Synthesis, Vinia polyphenols, piceid resveratrol, nitric oxide production, ET1 reduction, arterial dilation, vascular flexibility, blood flow optimization, brain oxygenation, cognitive alertness, oxidative stress reduction, bioavailable polyphenols, grape cell technology, olive cell compounds, verbascoside research, saffron cell cultivation, clinical blood flow studies, endothelial function, longevity supplementation **Visti www.vinia.com/Dave - for a generous discount on your next purchase** Resources: • VINIA Website: www.vinia.com/Dave • BioHarvest Website: https://bioharvest.com/• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 1:30 - How BioHarvest Works 5:23 - Piceid Resveratrol & Clinical Studies 13:37 - Blood Flow & Cardiovascular Benefits 17:08 - Brain Health & Cognitive Effects 20:07 - VINIA Product Line & Pricing 22:33 - Nitric Oxide Mechanism & ET1 26:39 - Chews & Hydration Mix 36:35 - VINIA Heroes Program 41:19 - Olive Cell Technology & Verbascoside 45:13 - Pharmaceutical Implications 51:30 - Saffron Development See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • The Machine That Flicks on Your Brain in 30 Seconds | Biohacker Tools : 1373
    This episode shows you how light, vibration, and frequency-based technology can shift your brain state in minutes, unlock deep neuroplasticity, release stored trauma, and create coherence that normally takes years of meditation or psychedelic training. You will learn how these tools support performance, resilience, mitochondria, emotional regulation, and advanced biohacking. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with master healer Raffaele Gianfrancesco, whose work draws on energy medicine, Egyptian color healing, vibroacoustics, and light based entrainment. Raffaele trained in the Barbara Brennan lineage and spent years developing methods that shut down the default mode network, activate the thalamocortical circuit, and move people into deep meditative and altered states within minutes. His technology has attracted the attention of consciousness researchers, advanced meditation schools, ketamine clinics, and U. S. Air Force programs studying human resilience and pilot performance. Dave and Raffaele break down how vibroacoustic sound, harmonics, cymatics, and flickering light therapy guide the brain into gamma, delta, epsilon, and high resonance states that support clarity, emotional release, and rapid state change. Raffaele explains how vibration affects fascia and trauma storage, how light influences the cerebrospinal fluid and pineal gland, and why coherence is the key to shifting consciousness. They discuss ketamine assisted therapy, remote viewing, the Monroe Institute, the relationship between frequencies and brain states, the history of flickering light therapy, and how certain frequencies help loosen trauma patterns stored in the body. You’ll Learn: • How vibroacoustic sound and coherent light shut down the default mode network • Why fascia, trauma memory, and cerebrospinal fluid respond to vibration • How flicker based entrainment maps to gamma, delta, and theta brain states • Why the Air Force studies these tools for resilience and reaction speed • How ketamine combines with vibration and light to improve neuroplasticity • Why coherence, awe, and safety cues are essential for deep emotional release • What cymatics, harmonics, and frequency patterns reveal about consciousness Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibroacoustic therapy, flickering light therapy, consciousness technology, brainwave entrainment, cymatics healing, trauma release tools, ketamine neuroplasticity, default mode network reset, cerebrospinal fluid flow, energy medicine, Barbara Brennan healing, harmonic frequencies, gamma brain states, theta induction, somatic healing, astral plane experiences, remote viewing training, Monroe Institute methods, coherence training, vibration based meditation **https://roxiva.com/dave - for $1,000 off when you purchase the light and vibroacoustic bed together. ** Resources: • RoXiva Website: https://roxiva.com/dave • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: • 0:00 - Introduction • 1:14 - Vibroacoustic Technology • 4:08 - Energy Medicine and Healing • 10:06 - Coherence and Harmonics • 13:47 - Flickering Light Therapy • 16:10 - Stanislav Grof and LSD • 18:49 - Soul Sickness and Consciousness • 21:53 - Ayahuasca and Astral Plane • 28:36 - Psychedelics and Ego Death • 31:23 - Ketamine and Neuroplasticity • 37:31 - Trauma and Presence • 41:08 - Harmonics and Brain Frequencies • 44:04 - Flicker Fusion and Safety • 46:43 - Remote Viewing and Monroe Institute • 48:23 - Cerebrospinal Fluid and Consciousness • 50:32 - Product Details and Pricing See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • How I Lost 100 Pounds By Drinking Butter Coffee : 1371
    In 1999, a Silicon Valley millionaire on the brink of collapse took one mysterious sip atop a frozen Tibetan mountain - and everything changed. That moment sparked a global movement, rewrote the rules of fat and energy, and turned an ancient secret into a modern revolution.00:00 – The Dying Millionaire00:40 – The Mountain That Changed Everything01:30 – The Birth of Bulletproof Coffee02:40 – When the World Took Notice03:45 – The Fat Lie We All Believed04:45 – The Truth About Good Fats06:00 – Escaping the Sugar Trap07:15 – Stop Counting Calories09:00 – Why Inflammation Keeps You Fat10:40 – Eat Less Often, Not Less Food12:00 – The Exercise Myth13:40 – The Hidden Toxins Problem15:20 – Fixing the Root Cause17:40 – The Power of Mitochondria20:00 – One Sip That Changed EverythingThank you to our sponsors! -KILLSwitch | If you’re ready for the best sleep of your life, order now at https://www.switchsupplements.com/ and use code DAVE for 20% off.-EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.Connect with Dave Asprey!Website: https://daveasprey.comTikTok: https://www.tiktok.com/@daveaspreyofficialInstagram: https://www.instagram.com/dave.asprey/Facebook: https://www.facebook.com/Daveaspreyofficial/X: https://x.com/daveaspreyYouTube: https://www.youtube.com/c/daveaspreybprThe Human Upgrade Podcast: Instagram: https://www.instagram.com/TheHumanUpgradePodcast/ Facebook: https://m.facebook.com/Thehumanupgrade/Resources: • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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  • Get a Full Body Workout in 10 Minutes by Doing NOTHING | Biohacks : 1372
    Most people think you need sweat, strain, or long workouts to upgrade circulation, metabolism, and energy. What if your body could unlock all of that while you stand still? This episode reveals how to get a full body workout by doing absolutely nothing, and why a few minutes of targeted vibration can activate nitric oxide, improve microcirculation, calm your nervous system, and relieve the hidden damage from sitting all day. Host Dave Asprey shows you why the simplest biohack in the room might be the most powerful one you are not using. Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR Host Dave Asprey sits down with Dr. Tommy Rhee, DC, a board-certified chiropractor known for his innovative approach to sports medicine and regenerative therapy. Dr. Rhee has treated professional athletes, starting NFL quarterbacks, and everyday people who want better mobility and faster recovery. He served as the official team chiropractor for the Tampa Bay Buccaneers and worked with multiple UCLA athletic programs. He also created RheeGen, a patent-pending topical transdermal stem cell cream that introduces a non-invasive path to tissue repair and pain relief. His book, The Future of Regenerative Medicine, outlines how topical stem cell treatments can transform performance and healing. Dr. Rhee’s background as a U.S. Navy aircrew member aboard S-3 Viking jets gives him a precision-driven understanding of human performance, resilience, and stress adaptation. In this episode, Dr. Rhee explains why whole body vibration works as a cheat code for circulation, fascia mobility, balance, mood, and nitric oxide activation. He shows how vibration increases microcirculation in places your workouts never reach, why it boosts lymphatic flow better than walking, and how it sends rapid-fire sensory signals that improve proprioception and stress recovery. You also learn why older adults benefit even more from this simple tool, how athletes use it as a warmup to conserve energy, and why three plane vibration dramatically outperforms cheap two dimensional devices. Dave and Dr. Rhee show you how to pair vibration with fasting, ketosis, nootropics, supplements, Danger Coffee, and Smarter Not Harder style training for maximum biohacking efficiency. You’ll Learn: • How to mimic the benefits of a full workout while standing still • Why nitric oxide drives circulation, longevity, and metabolic health • How vibration accelerates lymphatic drainage and clears stagnation • Why whole body vibration improves balance, sensory speed, and neuroplasticity • How athletes warm up with vibration to protect energy reserves • Why triplanar vibration beats two dimensional devices for real results • How vibration supports pelvic floor strength and erectile function • How to use vibration for joint protection, fascia mobility, and mitochondrial activation • The daily protocol Dr. Rhee uses for stress relief, mood, and brain optimization Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights in health, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living. New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient. Keywords: vibration plate benefits, power plate workout, whole body vibration therapy, nitric oxide boost naturally, improve circulation fast, lymphatic drainage at home, fix leg swelling quickly, better than walking workout, passive exercise machine, joint friendly fitness, biohacking circulation hack, vibration plate for balance, how to increase microcirculation, proprioception training at home, vibration plate for seniors, rebounder vs vibration plate, fix poor circulation in legs, vibration therapy recovery, power plate warmup routine, best vibration plate for home use **Discount on your next Power Plate: https://powerplate.com/dave ** Resources: • Power Plate Website: https://powerplate.com/dave• Dr. Tommy Rhee’s Website: https://rheegen.com/ • Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today. • Danger Coffee: https://dangercoffee.com/discount/dave15 • My Daily Supplements: SuppGrade Labs (15% Off) • Favorite Blue Light Blocking Glasses: TrueDark (15% Off) • Dave Asprey’s BEYOND Conference: https://beyondconference.com • Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated • Upgrade Collective: https://www.ourupgradecollective.com • Upgrade Labs: https://upgradelabs.com • 40 Years of Zen: https://40yearsofzen.com Timestamps: 0:00 - Trailer 0:45 - Introduction: Whole Body Vibration 2:12 - Biological Activation Explained 4:05 - Nitric Oxide and Circulation 5:57 - Power Plate vs Walking 8:19 - Shearing Force and Fascia 11:25 - Planking and Exercise Variations 13:31 - Common Mistakes 15:03 - Microcirculation and Lymphatics 19:02 - Benefits for Young Athletes 22:15 - Types of Vibration Machines 25:21 - Proprioception and Balance 27:08 - Pro Athletes and Warm-Up 34:08 - Benefits for Women 35:35 - Benefits for Men 36:13 - Mood and Stress Relief 37:21 - Power Plate Deal and Recommendations 38:53 - Frequency Settings 40:58 - Power Plate vs Rebounder 44:03 - Usage for Ill or Elderly 46:53 - Closing Thoughts See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.
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Über The Human Upgrade: Biohacking for Longevity & Performance

For more than a decade, Dave Asprey - the Father of Biohacking and creator of Bulletproof Coffee - has redefined what’s possible for the human mind and body. After more than a thousand episodes of Bulletproof Radio, he’s taking it to the next level with The Human Upgrade™ - a masterclass in biohacking, longevity, and performance optimization.Each episode explores cutting-edge science, advanced technology, and proven biohacks to help you upgrade your energy, focus, metabolism, and resilience. You’ll learn from world-class scientists, doctors, innovators, and thinkers leading breakthroughs in mitochondrial health, peptides, hormones, fasting, sleep, neuroplasticity, and more.This isn’t just self-improvement - it’s human enhancement backed by data.Every guest, every idea, every protocol you discover here moves you toward a longer, stronger, smarter life.Join The Human Upgrade™ with Dave Asprey - and learn how to live longer, think faster, and perform better.
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