The Human Upgrade: Biohacking for Longevity & Performance

Subtitle: A Nasal Spray Longevity Screen, Why Less Protein May Age You Better, Cadaver Skin Injectables, Art's Effect on Biological Age, and Which Anti-Aging Interventions Actually Move the Needle

Nasal Spray Ingredient Emerges As Unexpected Longevity Candidate In Massive Drug Screen
Researchers mapped 2,358 longevity-associated genes across the body's broader protein and signaling networks, then screened 6,442 approved drugs to see which ones nudged those aging pathways in a healthier direction. Oxymetazoline, the active ingredient in nasal sprays like Afrin, was among 21 standout candidates, with a predicted pathway running through the ACKR3 receptor and connecting to major aging proteins including NF-kB, TP53, and AKT1. Host Dave Asprey explains why this computational screen is a promising research lead rather than a protocol, and why chronic use of a vasoconstricting nasal spray carries real risks regardless of what a network analysis suggests.
Sources:
https://www.inc.com/lucia-auerbach/scientists-screened-6442-drugs-for-longevity-common-nasal-spray-emerged-as-a-surprising-candidate/91381000
https://www.sciencealert.com/medications-already-in-pharmacies-may-slow-aging-and-scientists-are-narrowing-them-down
https://pmc.ncbi.nlm.nih.gov/articles/PMC12425021/

~~
New Review Of 350+ Studies Asks Whether Less Protein Means Longer Life
A review spanning more than 350 studies found that protein restriction consistently extended lifespan and improved metabolic health across mice, rats, flies, and fish, with smaller human studies showing improvements in body fat and fasting glucose even when total calorie intake rose. Researchers point to FGF21, a liver hormone that rises under protein or amino acid scarcity and boosts energy expenditure and glucose regulation, as a key mechanism. Host Dave Asprey breaks down why blanket protein advice fails older adults preserving muscle and highly active people just as badly as it fails everyone else, and why matching intake to actual biology beats maximizing protein at every meal.
Sources:
https://www.medicalnewstoday.com/articles/why-reducing-protein-intake-could-promote-healthy-aging-new-research
https://time.com/article/2026/08/03/eat-less-protein-age-better-live-longer/
https://www.sciencedaily.com/releases/2026/08/260801042811.htm
https://www.cell.com/cell-reports-blue/fulltext/S2949-8821(26)00079-9
https://pmc.ncbi.nlm.nih.gov/articles/PMC8991228/
https://www.eurekalert.org/news-releases/1137190

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Processed Cadaver Skin Injectable Enters The Anti-Aging Market As Elravie Re2O
A new injectable called Elravie Re2O, short for "return to your 20s," is made from donated human skin processed to remove living cells and most genetic material, leaving a collagen-rich extracellular matrix that gets injected into the face and neck as a biological scaffold rather than a simple filler. Human-derived tissue matrices already have a track record in burn and wound care, but this specific product is not yet FDA-approved and lacks comparative trial data against existing fillers. Host Dave Asprey separates legitimate regenerative medicine from a novel cosmetic product still waiting on long-term safety and consistency data.
Sources:
https://nypost.com/2026/07/21/health/the-hottest-new-anti-aging-treatment-cadaver-skin/
https://www.newsobserver.com/living/article316698211.html
https://www.miamiherald.com/living/article316698295.html
https://pmc.ncbi.nlm.nih.gov/articles/PMC12985180/
https://laboderm-skin.com/elravie-re2o-application/

~~
UCL Study Finds Weekly Arts Engagement Tracks With Slower Epigenetic Aging
A University College London study of more than 3,500 adults found that people who engaged weekly with arts and culture, including painting, music, museums, and theater, showed a roughly four percent slower pace of aging on the DunedinPACE clock and appeared about one biological year younger on PhenoAge, with the effect holding after adjusting for income, education, smoking, and physical activity. Benefits appeared whether people were actively creating art or simply attending performances and exhibits. Host Dave Asprey argues this expands what counts as a health input beyond molecules and devices, since novelty, meaning, and social connection influence the nervous system too.
Sources:
https://www.npr.org/2026/05/12/nx-s1-5818172/study-arts-slow-biological-aging
https://www.news-medical.net/news/20260511/Regular-arts-engagement-may-help-slow-biological-aging-process.aspx
https://studyfinds.com/arts-culture-may-slow-aging/

~~
Review Of 41 Human Studies Ranks Which Interventions Actually Shift Epigenetic Clocks
A review of 41 human studies testing interventions against newer-generation epigenetic clocks found favorable changes for exercise, caloric restriction, omega-3s, plant-rich diets, multivitamins, semaglutide, pitavastatin, and ketamine, while nicotinamide riboside, rapamycin, and senolytics showed no detected clock improvement in the studies reviewed. Semaglutide produced the strongest single result, slowing DunedinPACE by about nine percent in a trial of adults with HIV-associated fat redistribution, though a separate fatty liver study produced mixed outcomes. Host Dave Asprey explains why a strong mechanistic story does not guarantee a moved biomarker, and why clinical outcomes, functional measures, and safety data all matter alongside any single clock reading.
Sources:
https://www.frontiersin.org/journals/genetics/articles/10.3389/fgene.2026.1836446/full
https://pubmed.ncbi.nlm.nih.gov/42294499/
https://www.news-medical.net/news/20260616/Semaglutide-omega-3s-and-diet-shift-epigenetic-aging-clocks-in-human-studies.aspx
https://www.nature.com/articles/s41514-026-00383-9
https://pmc.ncbi.nlm.nih.gov/articles/PMC12338914/
https://medicalxpress.com/news/2026-06-popular-glp-drug-biological-aging.html
https://www.creativebiomart.net/blog/semaglutide-may-slow-epigenetic-aging-in-humans
https://www.aging-us.com/article/202913/text
https://superpower.com/guides/can-you-reverse-epigenetic-age
https://www.nature.com/articles/d41586-026-01836-7
https://www.businessinsider.com/first-ever-reverse-aging-drug-was-just-injected-into-a-human-2026-6
~~

This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into a computational drug-repurposing screen, the case for eating less protein, a new regenerative injectable made from human tissue, the biological effect of creative engagement, and a data-driven ranking of which longevity interventions actually move epigenetic clocks. Host Dave Asprey connects computational biology, nutrition science, regenerative medicine, and biomarker research into practical frameworks for evaluating what belongs in a real longevity protocol versus what belongs on a watch list.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: oxymetazoline longevity, drug repurposing screen aging, ACKR3 receptor aging pathway, protein restriction longevity, FGF21 hormone aging, low protein diet healthspan, cadaver skin injectable, Elravie Re2O, extracellular matrix regenerative medicine, anti-aging injectable 2026, arts engagement biological age, DunedinPACE epigenetic clock, PhenoAge biological age, epigenetic clock interventions, semaglutide epigenetic aging, rapamycin epigenetic clock, senolytics human trials, biological age testing, biohacking news 2026, Dave Asprey, The Human Upgrade

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Resources:
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Timestamps:
00:00 – Intro
00:19 – Anti-Aging Drug Screening
01:43 – Protein Restriction & Aging
03:36 – New Skin Injectable
05:23 – Arts & Longevity
07:30 – Biohacking Interventions Reviewed
08:51 – Semaglutide & Aging Clocks
09:29 – Closing Thoughts
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The Orgasm Code: How Pleasure Rewires Your Nervous System for Longevity & Healing | Regena Thomashauer (Mama Gena)

Most people think pleasure is a distraction from performance. This episode proves the opposite: your orgasm is a biohacking tool wired directly into your nervous system, your hormones, and your longevity.

Watch this episode on YouTube for the full video experience: https://www.youtube.com/@DaveAspreyBPR

Host Dave Asprey sits down with Regena Thomashauer, known worldwide as Mama Gena, founder and CEO of the School of Womanly Arts and a New York Times bestselling author. For over three decades she has taught hundreds of thousands of women how to reclaim pleasure as a source of power, and her work has redefined what modern feminism and embodiment look like in practice.

Dave and Regena break down the actual biology behind orgasm: the oxytocin, prolactin, and endorphin cascade that shifts the body out of fight or flight and into repair, the role of sleep optimization in processing trauma, and how chronic disconnection from pleasure keeps people stuck in survival mode instead of human performance mode. They dig into semen retention research and its link to longevity and anti-aging, why shame around the body blocks neuroplasticity and emotional healing, and how learning to regulate arousal, rage, and surrender is its own form of nervous system hacking. This is a masterclass in reclaiming a part of your biology most people were never taught to understand, let alone optimize.

This is essential listening for anyone serious about biohacking, human performance, brain optimization, functional medicine, longevity, and building a body and mind that can hold more pleasure, more power, and more presence.

You'll Learn:
How orgasm triggers an oxytocin, prolactin, and endorphin cascade that lowers cortisol and drives real nervous system repair
Why the Daoist approach to semen retention is tied to longevity and anti-aging in men
How chronic shame and disconnection from the body block neuroplasticity and keep trauma stuck
The link between sleep optimization, hormone regulation, and processing deep emotional wounds
How to move rage and grief through the body instead of suppressing them
Why relaxation, not effort, is the real key to expanding pleasure and human performance
How devotional presence between partners creates measurable shifts in nervous system state

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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: Mama Gena, Regena Thomashauer, On Our Knees book, Pussy A Reclamation, School of Womanly Arts, orgasm and oxytocin, prolactin endorphins orgasm, extended orgasm training, semen retention benefits, Daoist orgasm practices, Lafayette Morehouse, truth tantrum tender tantrum, clitoris anatomy explained, vulva versus vagina, goddess archetypes women, embodiment practice trauma, devotion versus attention, Dave Asprey Mama Gena, female pleasure biohacking, nervous system relaxation orgasm

Resources:
• Order Regena’s New Book On Our Knee’s and visit her website at: https://mamagenas.com/books/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
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• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
01:21 –Intro
07:24 – Orgasm saved my life
16:34 – The body's medicine cabinet
20:08 – Meaning of On Our Knees
27:34 – Betrayal and forgiveness
37:05 – Righteous anger vs. stridence
47:02 – Semen retention practice
52:51 – Energetic heart connection
01:00:53 – Daoist orgasm equations
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The Gut-Lung Axis: The Missing Link in Chronic Inflammation & Aging | Dr. Vivek Lal

Your lungs have a microbiome, and almost no one is talking about it. This episode reveals the hidden pathway behind asthma, chronic inflammation, and slow aging, and gives you a science-backed way to biohack your breath from the inside out.

Get A generous discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’

Host Dave Asprey sits down with Dr. Vivek Lal, MD, FAAP, a double board-certified physician scientist who discovered the gut-lung axis while running the Pulmonary Microbiome Lab at the University of Alabama at Birmingham. He serves as Director of Clinical Innovation at UAB's Marnix Heersink Institute of Biomedical Innovation and trained in pulmonary and vascular biology at UT Southwestern before completing MIT's executive program in drug and device development. As a serial entrepreneur through his venture studio Biostack Ventures, he founded and now serves as CEO of Resbiotic Nutrition, and also launched Alveolus Bio, an FDA-track pulmonary drug development company. His decade of research turned into the world's first probiotic built specifically for respiratory health.

Dave and Vivek break down MMP-9, the overlooked inflammatory pathway that drives collagen breakdown, chronic lung disease, and accelerated aging throughout the body. They cover why germ-free mice outperform normal mice, how antibiotics and toxic mold reshape your lung bacteria for years, why breathwork actually changes your lung microbiome, and how postbiotics and inhaled probiotics could become the next frontier in functional medicine. Along the way they get into supplement formulation, drug development red tape, and why self-experimentation should be treated as a right, not a privilege.

You'll Learn:
What the gut-lung axis is and how gut bacteria control inflammation in your lungs
Why MMP-9 may be the next major longevity pathway after sirtuins
How antibiotics, toxic mold, and vaping damage your lung microbiome long term
Why breathwork and lung training measurably change your lung bacteria
How postbiotics and inhaled probiotics could replace inhalers and steroids
Why product-level clinical testing matters more than single-ingredient hype
How self-experimentation, AI, and personalized data are reshaping medicine

Thank you to our sponsors!
- ELITE Performance Coaching | If you’d like to discover where you may be addicted to struggle, allergic to success, and what may be standing between you and your next breakthrough, visit FastestChange.com
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: gut-lung axis, lung microbiome, MMP-9 inflammation pathway, Resbiotic review, does Resbiotic work, Resbiotic lung support, Dr. Vivek Lal, gut-lung axis probiotic, lung microbiome science, MMP-9 longevity pathway, MMP-9 collagen breakdown, best probiotic for lung health, probiotics for asthma, probiotics for allergies, inhaled probiotics FDA, postbiotics for inflammation, NLRP3 inflammasome, NF-kappa B pathway, breathwork lung microbiome, toxic mold lung bacteria, antibiotics lung damage, biohacking respiratory health, lung microbiome 2026, resbiotic.com discount code DAVE20, functional medicine for lungs, quit vaping lung health

Resources:
• Get a discount on Resbiotic by going to: https://resbiotic.com/ and using code ‘DAVE20’
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Cold Open
01:08 – Intro
05:17 – Discovering the Lung Microbiome
16:58 – Antibiotics' Effect on Lungs
20:30 – MMP-9 Explained
25:56 – NLRP3 & the Inflammasome
31:36 – The Right to Self-Experiment
42:04 – Lung Training
1:00:18 – Astronaut Microbiomes
1:12:33 – Closing & Discount Code
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There is one molecule your body already makes that helps protect your cells from aging, but your production of it drops as you get older.

In this video, I explain why glutathione is known as the body’s master antioxidant and why it plays a critical role in cellular defense, mitochondrial energy, immune regulation, and liver detoxification.

You’ll discover why aging is not just your body “wearing out,” but the slow breakdown of your internal repair and antioxidant defense systems.

You’ll also learn:
-Why oxidative stress damages mitochondria and accelerates aging
-How glutathione helps protect cells from daily stress
-Why your liver uses huge amounts of glutathione for detox support
-The difference between oral, liposomal, IV, and topical glutathione
-Why delivery matters if you want your body to actually use it
-How to stack glutathione with sleep, protein, sunlight, training, and sauna

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
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00:00 – Intro: The Anti-Aging Molecule
02:59 – The Vicious Decline Cycle
04:15 – Step 1: Lower Oxidative Load
05:00 – Step 2: Support Mitochondria
05:41 – Introducing Glutathione
08:54 – Oral & Liposomal Glutathione
10:02 – IV Glutathione
10:17 – Topical/Transdermal Delivery
11:23 – The Glutaryl Solution
12:47 – Daily Routine & Final Thoughts

Connect with Dave Asprey!
Website: https://daveasprey.com
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Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
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Viagra's Cancer Signal, TV's Toll on Your Brain, Heat and Accelerated Aging, and a New Way to Flush Your Brain Explained

Viagra's Active Ingredient May Block Cancer From Spreading
A study published in Cancer Research from the Weizmann Institute of Science, in collaboration with Clalit and the U.S. National Cancer Institute, found that sildenafil, the active ingredient in Viagra, may interfere with cancer cells' ability to metastasize by disrupting how they regulate cholesterol, a resource tumors need to detach and invade new tissue. The team combined mouse models and human cell cultures with more than twenty years of medical records covering roughly five million people, and found better survival outcomes among about forty thousand cancer patients who had taken sildenafil before diagnosis. Researchers also flagged a possible combination effect with statins. Host Dave Asprey breaks down why this cheap, off-patent drug class deserves more attention than it's getting, and where it fits alongside his own longevity protocol.
Source:
https://www.healthline.com/health-news/viagra-may-stop-cancer-from-spreading-study
~~

Heavy TV Watching In Midlife Tied To Alzheimer's-Related Brain Changes
A nearly twenty-four-year study published in Alzheimer's & Dementia followed more than 1,700 adults, tracking TV habits in their early fifties and scanning their brains in their mid-seventies. Men who watched more TV showed greater white matter damage and smaller frontal and occipital lobes, while women showed no such association. Critically, people with desk jobs that kept them sedentary all day did not show the same brain changes, and the TV association held even after adjusting for exercise levels. Host Dave Asprey unpacks why passive screen time, not sitting itself, may be the real driver here.
Sources:
https://www.the-independent.com/life-style/tv-time-linked-alzheimers-study-b3023054.html
https://alz-journals.onlinelibrary.wiley.com/doi/10.1002/alz.71582
~~

Ambient Heat Exposure Linked To Faster Biological Aging
A Science Advances study of 3,686 older adults linked neighborhood-level heat index exposure to accelerated biological aging using DNA methylation clocks. Short-term heat exposure moved one clock significantly, while exposure sustained over a full year or six years moved all major clocks, with extreme-caution heat days tied to nearly a three-year jump in one aging measure and a five percent faster overall aging pace on another. Researchers point to inflammation and stress signaling as likely drivers. Host Dave Asprey explains why this is a fundamentally different kind of heat story than the sauna and cold-plunge conversation biohackers are used to.
Source:
https://www.science.org/doi/10.1126/sciadv.adr0616
~~

Industrial Chicken Farming May Be Accelerating The Spread Of Drug-Resistant Bacteria
A genomic analysis of nearly 2,800 bacterial samples from chickens and wild birds across thirty countries, published in PNAS and covered by The Guardian, found a roughly hundredfold increase in Campylobacter strain transitions between wild birds and farmed chickens since 1900. Global chicken populations have grown sevenfold since the 1960s to about 27 billion birds, and researchers identified genetic adaptations tied to antimicrobial resistance developing inside that population. Sixty to eighty percent of human Campylobacter infections trace back to raw chicken, with links to post-infectious IBS in some cases. Host Dave Asprey connects the dots between industrial farming density and the gut-health stakes for anyone who eats chicken.
Sources:
https://www.theguardian.com/food/2026/jul/27/industrial-chicken-farming-accelerating-spread-of-diarrhoea-bacteria-study-finds
https://doi.org/10.1073/pnas.2609969123
~~

VA Researchers Develop Breathing-Based "Brain Flush" For Parkinson's And Alzheimer's
VA researchers led by Dr. Henry Lin found a way to trigger the brain's glymphatic clearance system, normally active during deep sleep, in people who are awake, using alternating puffs of five percent carbon dioxide and room air every thirty-five seconds. In a study of thirty Parkinson's patients and thirty-three healthy controls, a single thirty-minute session produced measurable increases in blood levels of beta-amyloid, alpha-synuclein, and other waste proteins associated with neurodegeneration. The VA's Technology Transfer Program is now developing a patent and prototype device. Host Dave Asprey explains why this gives breathwork protocols a real physiological mechanism instead of just a hunch.
Source:
https://www.research.va.gov/currents/0426-Exciting-new-treatment-being-developed-for-Parkinsons-Alzheimers.cfm
~~~

This episode is designed for biohackers, longevity enthusiasts, and high-performance listeners who want mechanism-level insights into an overlooked cancer drug repurposing story, the real difference between passive and active screen time, a new angle on heat as a biological stressor, the hidden gut-health cost of industrial poultry farming, and a breathing technique that may unlock your brain's own detox system. Host Dave Asprey connects clinical research, large-scale genomic data, and translational neuroscience into practical frameworks for improving longevity, gut health, and brain performance.

New episodes every Tuesday, Thursday, Friday, and Sunday.

Keywords: sildenafil cancer metastasis, Viagra cancer research, cholesterol cancer cells, PDE5 inhibitor longevity, TV Alzheimer's risk, screen time dementia, white matter brain aging, passive sedentary behavior brain, ambient heat epigenetic aging, DNA methylation clock, heat index biological aging, industrial chicken farming bacteria, Campylobacter antibiotic resistance, foodborne illness IBS, glymphatic system brain flush, CO2 breathing brain detox, Parkinson's Alzheimer's treatment, VA brain research, biohacking news 2026, Dave Asprey, The Human Upgrade

Thank you to our sponsors!
- Suppgrade Labs | Get real restorative sleep with Quiet Mode. Use code DAVE15 at shopsuppgradelabs.com.
- Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Get My 2026 Biohacking Trends Report: https://daveasprey.com/2026-biohacking-trends-report/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Intro
00:19 – Story #1: Viagra & Cancer
02:01 – Story #2: TV Watching & Brain Aging
03:16 – Story #3: Heat Exposure & Biological Age
04:46 – Story #4: Chicken Farming
06:34 – Story #5: CO2 Therapy & Brain Detox
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.