The Human Upgrade: Biohacking for Longevity & Performance

Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything)

Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there.

Use code DAVE for a discount at aurowellness.com/dave

Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Ora Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking.

Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects.

You'll Learn:
Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it
How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging
Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year
Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione
The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere
Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one
A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer
Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it


Thank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
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Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine

Resources:
• Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave
• Learn More About Dr. Patel’s work at: https://aurowellness.com/pages/dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:43 – Episode Intro
03:16 – Glutathione Basics
07:34 – Senescent Cells
11:07 – Cellular Delivery Science
14:20 – GlyNAC Precursors
21:37 – Amino Acid Ratios
25:18 – GHK Copper Peptide
28:41 – Purity & Manufacturing
31:34 – Glutathione vs. NAD
33:49 – Absorption Studies
37:51 – Heavy Metals & Toxins
42:35 – Alcohol & Glutathione
47:43 – Mortality & Reincarnation
49:54 – GLP-1s & Anhedonia
53:25 – Future of Peptides
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cardiologist Dr. Peter McCullough on mRNA Persistence, Nattokinase, and the Fight Over COVID-19 Treatment"

Six years after standing before the US Senate and calling out the pandemic response in real time, Dr. Peter McCullough returns with new evidence on where the spike protein came from, how long it persists in the body after infection or vaccination, and what's being done to break it down. This episode traces the science from a 2015 gain-of-function paper to a patient still showing circulating spike protein 3.6 years after vaccination.

Get Dr. McCullough's free spike protein guide: myfreespikeguide.com

Host Dave Asprey sits down with Dr. Peter McCullough, a physician trained in internal medicine, cardiology, and epidemiology, and one of the most published and most censored voices of the COVID-19 pandemic. He authored the first multi-drug treatment protocol for COVID-19, testified before the US Senate in 2020 and again in 2025, and has published extensively in the peer-reviewed literature on vaccine safety, spike protein biology, and early treatment. His book Courage to Face COVID-19 and his most recent New York Times bestseller, Vaccines, Mythology, Ideology and Reality, examine the history and science behind vaccine policy.

Dave and Dr. McCullough trace the origins of the spike protein back to 2015 and 2016 research papers describing a lab-created, SARS-like coronavirus explicitly labeled "poised for human emergence," and discuss the funding, institutions, and researchers involved. They break down why synthetic mRNA vaccines resist the body's normal RNA breakdown process, what a patient case revealed about spike protein circulating 3.6 years after vaccination, and how nattokinase, a natural enzyme, has shown the ability to break the spike protein down. They also cover the suppression campaigns against ivermectin and hydroxychloroquine, the wartime propaganda origins of terms like "misinformation" and "anti-vaxxer," and what Dr. McCullough says he would do differently if he ran HHS. The conversation closes with new research on cognitive superagers, the small percentage of people who reach 100 with intact memory and health.

You'll Learn:
Why 2015 and 2016 research papers described a lab-created coronavirus as "poised for human emergence" years before the pandemic
Why synthetic mRNA in COVID-19 vaccines resists the body's natural RNA breakdown process
What one patient's case revealed about spike protein still circulating 3.6 years after vaccination
How nattokinase, a natural enzyme, has been shown to break down the spike protein
Why the FDA and FTC targeted ivermectin, hydroxychloroquine, and companies selling nasal sprays during the pandemic
The wartime propaganda origins of terms like "misinformation," "disinformation," and "anti-vaxxer"
What Dr. McCullough says he would do first if he were running HHS
What research on cognitive superagers reveals about the small number of people who reach 100 with intact health

Thank you to our sponsors!
- TrueDark | Visit truedark.com and use code DAVEASPREY15 (discount applies to all frames except Aegis)
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Qualia | Go to qualialife.com/ASPREY for 50% off, and use code ASPREY for an additional 15% off.
- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: spike protein detox, how long does spike protein last in your body, nattokinase spike protein, mRNA vaccine side effects, is the spike protein still in my blood, gain of function research explained, where did COVID come from, Wuhan lab leak evidence, ivermectin banned, why was hydroxychloroquine banned, vaccine injury compensation act, mRNA vaccine shedding, spike protein detox protocol, how to live to 100, cognitive superagers, Peter McCullough, Dave Asprey

Resources:
• Learn More About Dr. McCullough’s Work At: https://www.twc.health/pages/focal-points
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:43 – Intro
02:10 – 2020 Public Health Failures
05:07 – Vaccine History & Mythology
07:19 – Vaccine Hesitancy as Disease
13:12 – Masks & Lockdown Absurdity
18:03 – War on Hydroxychloroquine
23:56 – Ivermectin Suppression
28:58 – FTC Misinformation Crackdown
31:18 – Propaganda Terms Explained
39:55 – McCullough's Confidence & Career
43:08 – Spike Protein Origins
57:10 – Nattokinase & Spike Clearance
58:50 – mRNA Persistence in Body
1:11:50 – Fixing the System
1:17:32 – Political Divisiveness
1:22:41 – Secrets to Longevity
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A Nobel Prize-winning discovery revealed that your body has a built-in repair system that can help clear out old cellular damage and support healthier aging from the inside out.

In this video, Dave Asprey breaks down the strange Japanese breakfast ritual linked to some of the longest-living people on Earth, why modern life can shut down your body’s natural repair mode, and how one specific food may help wake it back up.

You’ll learn how this process supports brain clarity, energy, inflammation, recovery, and biological age, plus how to use it through food, supplements, sleep, exercise, and testing so you can actually track whether your body is responding.

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/

I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

Thank you to our sponsors!
Gatlan | Book your free consultation at www.gatlan.com/DAVE
The One Device | Use code DAVE for $10 off at theonedevice.com/dave
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:
0:00 – Japanese Breakfast Secret
1:02 – Damage vs. Repair
3:39 – What Is Autophagy?
6:03 – Natto & Longevity
7:34 – Using Spermidine Correctly
9:38 – The Under-Dosing Mistake
11:01 – Stacking Habits
12:21 – Measuring Biological Age
12:59 – Take Control of Your Biology

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
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YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Nervous System Hacking, Willpower vs Habit Systems, Calendar Time Blocking, and the Wallet Posture Fix Damaging Your Spine

Most people think surviving a life-threatening situation comes down to luck. Jordan Harbinger did it twice, and what got him out wasn't luck, it was a nervous system he had trained to override panic. This episode breaks down what actually happens in your body during a real fight-or-flight response, and how those same tools power his approach to human performance and hacking the excuses that keep most people stuck.

Host Dave Asprey sits down with Jordan Harbinger, founder of The Art of Charm, one of the top podcasts in the world on charisma, negotiation, and relationship building. Jordan built his expertise the hard way, surviving two real kidnapping attempts using the same psychological principles he now teaches to entrepreneurs and high performers. That firsthand experience under extreme pressure is exactly what makes his insight into stress, willpower, and behavior change worth trusting.

Jordan and Dave dig into what your nervous system does under real threat, why adrenaline hijacks rational thought, and how to build resilience that holds up when it matters most. They unpack why willpower fails as a long-term strategy, and why building smarter systems, not more discipline, is the real key to lasting change. Jordan breaks down his calendar-based productivity method, explains how sleep optimization and chronotype shape daily performance, and reveals a bizarre, physical habit quietly wrecking most people's spine and posture without them realizing it.

This is essential listening for anyone serious about biohacking, human performance, hacking the nervous system, brain optimization, neuroplasticity, and longevity, and building resilience that performs under real pressure, not just in theory.

You'll Learn:
How Jordan Harbinger used psychology to talk his way out of two real kidnapping attempts
What actually happens in your nervous system during a fight-or-flight response
Why willpower fails as a long-term strategy and what to build instead
How a calendar-based system eliminates decision fatigue and boosts daily performance
How sleep optimization and chronotype affect brain function and productivity
Why your wallet might be quietly damaging your spine and posture
How to rewire ingrained habits and reactions through neuroplasticity and awareness

Thank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
- EMR-Tek | https://www.emr-tek.com/DAVE and use code DAVE for 40% off.
- iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: fight-or-flight response, nervous system regulation, adrenaline and cortisol, stress physiology, psychological resilience, kidnapping survival, Jordan Harbinger, The Art of Charm, willpower vs systems, habit change, decision fatigue, calendar time blocking, productivity systems, chronotype, sleep optimization, posture and spine health, nervous system hacking, neuroplasticity, self-deception and excuses, high performance psychology, biohacking, human performance

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:58 – Guest Introduction
02:33 – First Kidnapping Story
06:54 – Second Kidnapping Story
14:25 – Escape & Evasion Training
23:26 – New Year's Resolutions
38:30 – Calendar Productivity System
51:45 – Wallet Audits & Minimalism
55:23 – Talking Your Way Out of Tickets
1:00:42 – Final Advice: Relationships
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Neurologist Dr. David Perlmutter Explains Brain Inflammation and Alzheimer's Risk

Your brain has its own immune system, and when it turns against you, it becomes the hidden driver behind Alzheimer's, Parkinson's, depression, and even long COVID. This episode hands you the science to recognize it early and reverse it.


Get Dr. Perlmutter’s new book Brain Defenders: https://drperlmutter.com/books/brain-defenders/


Host Dave Asprey sits down with Dr. David Perlmutter, a board-certified neurologist and six-time New York Times bestselling author whose work sits at the intersection of neurology, nutrition, and brain health. He is a Fellow of the American College of Nutrition, serves on its Board of Directors, and sits on the Editorial Board of the Journal of Alzheimer's Disease. His books, including the number one bestseller Grain Brain, span 32 languages and have sold over a million copies, and his upcoming release, Brain Defenders, explores the pivotal role of microglia, the brain's immune cells, in protecting, repairing, and reprogramming the brain for lifelong resilience.


Dave and Dr. Perlmutter break down how microglia, the brain's resident immune cells, shift from a supportive state into a destructive one called M1, and why this shift, not amyloid plaque, may be the real driver of Alzheimer's, Parkinson's, and other neurodegenerative conditions. They dig into why the leading amyloid-clearing drugs fail to improve cognition, what a landmark JAMA study revealed about reversing cognitive decline through lifestyle intervention alone, and why a single daily serving of ultra-processed food raised Alzheimer's risk by 13 percent in a 12.7 year study. They also cover new research on GLP-1 drugs and brain inflammation, the surprising role of gum disease and oral bacteria in dementia risk, and why 40 hertz light therapy is emerging as a low-cost tool for clearing brain plaque and calming neuroinflammation.


You'll Learn:
Why the shift from supportive to destructive brain immune cells may be the true root cause of Alzheimer's and Parkinson's
Why leading Alzheimer's drugs fail to improve cognition, and what the original research behind the amyloid hypothesis actually showed
How one daily serving of ultra-processed food raises Alzheimer's risk, and what a landmark lifestyle intervention study found instead
Whether GLP-1 drugs help or harm brain inflammation, based on new Parkinson's and Alzheimer's trial data
How gum disease and oral bacteria are linked to dementia, and simple daily habits that reduce that risk
Why 40 hertz light therapy is emerging as a tool to clear brain plaque and calm neuroinflammation
How ketones, DHA, and metabolic health protect the brain after head injury


Thank you to our sponsors!
- Beyond Wonderland Conference | Oct 13 - 14, 2026. Get your ticket now at wonderlandconference.com.
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Pique | Head over to Piquelife.com/Dave to get 20% off your order. That's P-I-Q-U-E life dot com slash DAVE
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.


Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.


New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.


Keywords: microglia, brain inflammation, Alzheimer's prevention, Parkinson's disease, amyloid hypothesis, neurodegeneration, GLP-1 drugs, semaglutide, ultra-processed food, gum disease and dementia, oral microbiome, 40 hertz light therapy, ketones, DHA, mitochondria, brain fog, long COVID, David Perlmutter, Brain Defenders, Grain Brain, functional medicine, biohacking, longevity, neuroplasticity


Resources:
• Get Dr. Perlmutter’s New Book Brain Defenders: https://drperlmutter.com/books/brain-defenders/
• Learn More About Dr. Perlmutter’s Work At: https://drperlmutter.com/
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com


Timestamps:
00:00 – Trailer
00:40 – Intro
02:38 – Ultra-Processed Foods
06:34 – Are Carbs Bad?
08:48 – Alcohol & Brain Health
12:28 – Microglia & Inflammation
24:37 – Head Injury & Recovery
29:27 – Oral Bacteria & Dementia
34:08 – GLP-1s & Brain Inflammation
40:20 – 40 Hertz Light Therapy
48:35 – Air Pollution vs. Lead
50:27 – David's Closing Truth
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.