The Human Upgrade: Biohacking for Longevity & Performance

Most people think biohacking is only for billionaires with access to expensive machines, private clinics, and million-dollar anti-aging protocols. But the truth is, some of the most powerful upgrades in your biology start with the basic signals your body receives every single day.

In this video, Dave Asprey breaks down how to start biohacking with around $200 by focusing on the foundations that control your sleep, energy, focus, and cellular repair. These are the simple changes that can create a massive difference before you ever spend money on advanced technology.

If you’ve ever wanted to feel sharper, recover better, sleep deeper, and support your body’s natural repair systems without wasting money on random gadgets, this video shows you where to start.

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I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

Thank you to our sponsors!
ECHO Water | Go to http://echowater.com/daveand use code DAVE10 for 10% off your ECHO Flask.
The One Device | Use code DAVE for $10 off at theonedevice.com/dave
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

00:00 – Trailer
00:53 – Sleep Environment Matters
03:44 – Red Light Bulbs
04:50 – Blackout Curtains
05:16 – Light-Blocking Glasses
07:16 – Morning Supplement Stack
07:41 – Creatine for the Brain
11:48 – MCT Oil Fuel
13:06 – Cellular Cleanup (Autophagy)
15:12 – Magnesium for Sleep
16:56 – Full Stack Recap
18:26 – Biohacking Is Accessibl

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Shawn Stevenson On The Science of Family Meals, Oxytocin, and Longevity

Your dinner table might be the most overlooked biohack in your house. This episode reveals the exact minimum dose of family meals that lowers a child's risk of obesity, the hormone your body releases every time you eat with people you love, and why teaching your kids to cook may protect their metabolism for life.

Host Dave Asprey sits down with Shawn Stevenson, founder of The Model Health Show and author of the bestselling Eat Smarter Family Cookbook series. Shawn spent over two decades studying nutritional science and functional medicine after recovering from advanced degenerative disc disease at age 20, and he has become one of the most trusted voices in health media for turning peer-reviewed research into real-world family habits.

Shawn and Dave break down the science of community eating, including new research on oxytocin, nervous system regulation, and metabolism that shows why sitting down together beats eating alone every time. They cover the four biological drives running your behavior, the connection between family culture and longevity, and how simple shifts like humming, breathwork, and intentional meals can support brain optimization and anti-aging at a cellular level. This conversation also dives into the five love languages hidden inside food, a bio-photon DNA experiment that reframes how energy moves between people, and the exact number of meals per week that changes a child's health trajectory.

You'll Learn:
The minimum effective dose of family meals per week that lowers childhood obesity and disordered eating
How oxytocin and a regulated nervous system change what happens at the dinner table
Why teaching kids to cook protects their metabolism and prevents dependence on ultra-processed food
How the five love languages show up in how you cook, serve, and share food
The bio-photon DNA experiment that shows how human energy fields affect the world around you
Why culture is something your family creates, not just something you inherit
How humming and breathwork practices can shift your nervous system and even change your voice

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade is the top podcast for people who want to take control of their biology, extend their longevity, and optimize every system in the body and mind. Each episode features cutting-edge insights in health, performance, neuroscience, supplements, nutrition, hacking, emotional intelligence, and conscious living.

Keywords: Shawn Stevenson, Dave Asprey, The Human Upgrade, biohacking, family dinner, family meals, community eating, longevity, functional medicine, oxytocin, nervous system regulation, childhood obesity, teaching kids to cook, five love languages, Model Health Show, Eat Smarter Family Cookbook, brain optimization, anti-aging, metabolism, nutrition science, mental health, family culture, healthy habits, minimum effective dose, human performance

Thank you to our sponsors!
-Gatlan | Book your free consultation at www.gatlan.com/DAVE
-Timeline | Visit timeline.com/dave to learn more about Mitopure and get 20% off your first order for a limited time
-iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Resources:
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Why Oral and IV Glutathione Never Actually Reach Your Cells (The Delivery Breakthrough Changing Everything)

Most of the supplements you're taking aren't failing you, they're failing to ever reach the cells that need them, and almost nobody selling them wants you to know that. This episode hands you the delivery breakthrough that actually gets it there.

Use code DAVE for a discount at aurowellness.com/dave

Host Dave Asprey sits down with Dr. Nayan Patel, a pharmacist, researcher, and founder of Auro Wellness, whose work centers on solving one of biohacking's most stubborn problems: getting nutrients past the bloodstream and into the cells that actually need them. He holds 14 patents in delivery technology, partners in the high-end longevity clinic Unlimited Life, and has spent over two decades studying glutathione, the master antioxidant his own research helped bring into modern biohacking.

Dave and Dr. Patel break down a 2011 University of Texas study showing that oral and liposomal glutathione are completely broken down into raw amino acids before absorption, meaning none of it reaches the bloodstream as glutathione, a pattern that holds true even for IV administration. They dig into new brain-imaging research showing topical glutathione crossing into neural tissue within 20 minutes, why senescent "zombie cells" may be directly tied to glutathione shortfalls, and why NAD, despite its reputation as the ultimate longevity molecule, is actually dependent on glutathione to do its job. They also cover the real purity ceiling on GHK-copper peptides, safe upper limits for glycine and NAC before they start working against you, a topical alcohol protocol that clears acetaldehyde without triggering a breathalyzer, and why oxidative stress from GLP-1 use is quietly driving one of the drug class's least-discussed side effects.

You'll Learn:
Why oral, liposomal, and even IV glutathione never actually reach your cells intact, and what a 2011 UT study proved about it
How topical glutathione was shown to cross into brain tissue within 20 minutes, and what that means for neurological aging
Why senescent "zombie cells" may be directly linked to glutathione shortfalls, and how one longevity clinic reversed markers by 70% in a year
Why NAD isn't the "ultimate longevity drug" it's marketed as, and its actual dependent relationship with glutathione
The real purity ceiling on GHK-copper peptides, and why 73% is currently the best available anywhere
Safe upper limits for glycine and NAC, and the oxalate crystal and Parkinson's-like risks of overdoing either one
A topical alcohol protocol that clears acetaldehyde fast enough to beat a breathalyzer
Why GLP-1 drugs are quietly driving oxidative stress, and what most patients are missing to counter it


Thank you to our sponsors!
- PredictiveMind™ | Get your Brain Pattern Mapping report at predictivemind.io/dave and use code DAVE for 10% off.
- OneSkin | Get 15% off OneSkin with the code DAVE at https://www.oneskin.co/DAVE #oneskinpod
- Caldera + Lab | A small habit with big results. Go to CalderaLab.com/DAVE and use code DAVE for 20% off your first order.
- Fatty15 is on a mission to support Healthy Aging for All, including all ages and stages of life. You can get an additional 15% off their 90-day subscription Starter Kit by going to fatty15.com and using code DAVE at checkout

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: glutathione, Nayan Patel, Ora Wellness, glutathione absorption, transdermal delivery, senescent cells, zombie cells, cellular aging, GHK-copper peptide, NAD, NAD supplements, NAC, glycine, GlyNAC, oxalate crystals, alcohol metabolism, acetaldehyde, GLP-1, semaglutide, oxidative stress, heavy metal detox, mercury toxicity, BPC-157, biohacking, longevity, functional medicine

Resources:
• Get A Discount On Auro Wellness Products - Use code DAVE: aurowellness.com/dave
• Learn More About Dr. Patel’s work at: http://aurowellness.com/dave
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/davetube
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:43 – Episode Intro
03:16 – Glutathione Basics
07:34 – Senescent Cells
11:07 – Cellular Delivery Science
14:20 – GlyNAC Precursors
21:37 – Amino Acid Ratios
25:18 – GHK Copper Peptide
28:41 – Purity & Manufacturing
31:34 – Glutathione vs. NAD
33:49 – Absorption Studies
37:51 – Heavy Metals & Toxins
42:35 – Alcohol & Glutathione
47:43 – Mortality & Reincarnation
49:54 – GLP-1s & Anhedonia
53:25 – Future of Peptides
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

Cardiologist Dr. Peter McCullough on mRNA Persistence, Nattokinase, and the Fight Over COVID-19 Treatment"

Six years after standing before the US Senate and calling out the pandemic response in real time, Dr. Peter McCullough returns with new evidence on where the spike protein came from, how long it persists in the body after infection or vaccination, and what's being done to break it down. This episode traces the science from a 2015 gain-of-function paper to a patient still showing circulating spike protein 3.6 years after vaccination.

Get Dr. McCullough's free spike protein guide: myfreespikeguide.com

Host Dave Asprey sits down with Dr. Peter McCullough, a physician trained in internal medicine, cardiology, and epidemiology, and one of the most published and most censored voices of the COVID-19 pandemic. He authored the first multi-drug treatment protocol for COVID-19, testified before the US Senate in 2020 and again in 2025, and has published extensively in the peer-reviewed literature on vaccine safety, spike protein biology, and early treatment. His book Courage to Face COVID-19 and his most recent New York Times bestseller, Vaccines, Mythology, Ideology and Reality, examine the history and science behind vaccine policy.

Dave and Dr. McCullough trace the origins of the spike protein back to 2015 and 2016 research papers describing a lab-created, SARS-like coronavirus explicitly labeled "poised for human emergence," and discuss the funding, institutions, and researchers involved. They break down why synthetic mRNA vaccines resist the body's normal RNA breakdown process, what a patient case revealed about spike protein circulating 3.6 years after vaccination, and how nattokinase, a natural enzyme, has shown the ability to break the spike protein down. They also cover the suppression campaigns against ivermectin and hydroxychloroquine, the wartime propaganda origins of terms like "misinformation" and "anti-vaxxer," and what Dr. McCullough says he would do differently if he ran HHS. The conversation closes with new research on cognitive superagers, the small percentage of people who reach 100 with intact memory and health.

You'll Learn:
Why 2015 and 2016 research papers described a lab-created coronavirus as "poised for human emergence" years before the pandemic
Why synthetic mRNA in COVID-19 vaccines resists the body's natural RNA breakdown process
What one patient's case revealed about spike protein still circulating 3.6 years after vaccination
How nattokinase, a natural enzyme, has been shown to break down the spike protein
Why the FDA and FTC targeted ivermectin, hydroxychloroquine, and companies selling nasal sprays during the pandemic
The wartime propaganda origins of terms like "misinformation," "disinformation," and "anti-vaxxer"
What Dr. McCullough says he would do first if he were running HHS
What research on cognitive superagers reveals about the small number of people who reach 100 with intact health

Thank you to our sponsors!
- TrueDark | Visit truedark.com and use code DAVEASPREY15 (discount applies to all frames except Aegis)
- ZenBud | Dave’s Nervous System Biohack. Visit zenbud.health and use code DAVE15 at checkout for a discount.
- Qualia | Go to qualialife.com/ASPREY for 50% off, and use code ASPREY for an additional 15% off.
- ENERGYbits | If you want a simpler, smarter way to support your body… this is it. Head to ENERGYbits.com and use code ASPREY for 20% off your order.

Dave Asprey is a four-time New York Times bestselling author, founder of Bulletproof Coffee, and the father of biohacking. With over 1,000 interviews and 1 million monthly listeners, The Human Upgrade brings you the knowledge to take control of your biology, extend your longevity, and optimize every system in your body and mind. Each episode delivers cutting-edge insights inhealth, performance, neuroscience, supplements, nutrition, biohacking, emotional intelligence, and conscious living.

New episodes are released every Tuesday, Thursday, Friday, and Sunday (BONUS). Dave asks the questions no one else will and gives you real tools to become stronger, smarter, and more resilient.

Keywords: spike protein detox, how long does spike protein last in your body, nattokinase spike protein, mRNA vaccine side effects, is the spike protein still in my blood, gain of function research explained, where did COVID come from, Wuhan lab leak evidence, ivermectin banned, why was hydroxychloroquine banned, vaccine injury compensation act, mRNA vaccine shedding, spike protein detox protocol, how to live to 100, cognitive superagers, Peter McCullough, Dave Asprey

Resources:
• Learn More About Dr. McCullough’s Work At: https://www.twc.health/pages/focal-points
• Get My 2026 Clean Nicotine Roadmap | Enroll for free at https://daveasprey.com/2026-clean-nicotine-roadmap/
• Dave Asprey's Latest News | Go to https://daveasprey.com/ to join Inside Track today.
• Danger Coffee: https://dangercoffee.com/discount/dave15?
• My Daily Supplements: SuppGrade Labs (15% Off)
• Favorite Blue Light Blocking Glasses: TrueDark (15% Off)
• Dave Asprey’s BEYOND Conference: https://beyondconference.com
• Dave Asprey’s New Book – Heavily Meditated: https://daveasprey.com/heavily-meditated
• Join My Substack (Live Access To Podcast Recordings): https://substack.daveasprey.com/
• Upgrade Labs: https://upgradelabs.com

Timestamps:
00:00 – Trailer
00:43 – Intro
02:10 – 2020 Public Health Failures
05:07 – Vaccine History & Mythology
07:19 – Vaccine Hesitancy as Disease
13:12 – Masks & Lockdown Absurdity
18:03 – War on Hydroxychloroquine
23:56 – Ivermectin Suppression
28:58 – FTC Misinformation Crackdown
31:18 – Propaganda Terms Explained
39:55 – McCullough's Confidence & Career
43:08 – Spike Protein Origins
57:10 – Nattokinase & Spike Clearance
58:50 – mRNA Persistence in Body
1:11:50 – Fixing the System
1:17:32 – Political Divisiveness
1:22:41 – Secrets to Longevity
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.

A Nobel Prize-winning discovery revealed that your body has a built-in repair system that can help clear out old cellular damage and support healthier aging from the inside out.

In this video, Dave Asprey breaks down the strange Japanese breakfast ritual linked to some of the longest-living people on Earth, why modern life can shut down your body’s natural repair mode, and how one specific food may help wake it back up.

You’ll learn how this process supports brain clarity, energy, inflammation, recovery, and biological age, plus how to use it through food, supplements, sleep, exercise, and testing so you can actually track whether your body is responding.

Try Danger Creatine: https://dangercoffee.com/products/danger-creatine
Try TrueDark glasses: https://truedark.com
Try Danger Coffee: https://dangercoffee.com/discount/davetube
Try Suppgrade Labs: https://shopsuppgradelabs.com/

I have spent twenty years and millions of dollars testing every legal focus drug I could get my hands on. In this video, I break down which compounds actually work, which ones are a waste of money, and the exact stack that delivers hours of clean focus without the afternoon crash.

The shift is simple: focus isn't a willpower problem. It's an energy production problem inside your brain. Once you fuel it at the cellular level, deep focus stops being a struggle and becomes the default state.

Thank you to our sponsors!
Gatlan | Book your free consultation at www.gatlan.com/DAVE
The One Device | Use code DAVE for $10 off at theonedevice.com/dave
iRestore | Reverse hair loss at www.irestore.com/DAVE and get exclusive savings on the iRestore Elite, use code DAVE

Timestamps:
0:00 – Japanese Breakfast Secret
1:02 – Damage vs. Repair
3:39 – What Is Autophagy?
6:03 – Natto & Longevity
7:34 – Using Spermidine Correctly
9:38 – The Under-Dosing Mistake
11:01 – Stacking Habits
12:21 – Measuring Biological Age
12:59 – Take Control of Your Biology

Connect with Dave Asprey!

Website: https://daveasprey.com
TikTok: https://www.tiktok.com/@daveaspreyofficial
Instagram: https://www.instagram.com/dave.asprey/
Facebook: https://www.facebook.com/Daveaspreyofficial/
X: https://x.com/daveasprey
YouTube: https://www.youtube.com/c/daveaspreybpr

The Human Upgrade Podcast: https://www.instagram.com/
TheHumanUpgradePodcast/ https://m.facebook.com/Thehumanupgrade/

Dave Asprey’s BEYOND Conference: https://beyondconference.com/
Dave Asprey’s New Book - Heavily Meditated: https://daveasprey.com/heavily-meditated/
Dave's favorite supplements: https://www.shopsuppgradelabs.com/discount/DAVE15
Upgrade Labs: https://upgradelabs.com
40 Years of Zen: https://40yearsofzen.com
See Privacy Policy at https://art19.com/privacy and California Privacy Notice at https://art19.com/privacy#do-not-sell-my-info.