Skin Anarchy

In this episode of Skin Anarchy, Dr. Ekta Yadav welcomes Carolina Reis Oliveira and Alessandra Zonari, co-founders of OneSkin, for a rigorous, eye-opening conversation that reframes skincare as a true longevity intervention. Part of the Lessons in Longevity series, this episode asks a bold question: what if skin aging isn’t cosmetic at all—but cellular, systemic, and deeply biological?
OneSkin began not as a brand, but as a lab-based mission. Trained in stem cell biology, tissue engineering, and genomics, Carolina and Alessandra spent years growing real human skin in the lab to test existing products. What they found challenged the industry: many so-called “anti-aging” formulas increased inflammation, cellular stress, and long-term damage. Meanwhile, longevity science was accelerating—yet skin, the body’s largest organ, was being left out of the conversation.
At the center of the episode is cellular senescence—a state where damaged cells stop dividing and begin secreting inflammatory signals that degrade surrounding tissue. In skin, this process weakens the barrier, disrupts collagen, and accelerates visible aging. Rather than masking symptoms, OneSkin set out to target this root cause. After screening hundreds of compounds, they developed OS-01, a proprietary peptide shown in lab models to significantly reduce senescent cell burden while increasing collagen—without irritation.
The conversation also expands beyond the face. OneSkin’s decision to focus on body skin revealed something unexpected: improving the skin barrier may reduce systemic inflammation. Clinical data discussed in the episode suggests that healthier skin doesn’t just look better—it may influence whole-body aging.
This episode is a must-listen for anyone curious about where skincare, biotech, and longevity science truly intersect.
Listen to the full episode of Skin Anarchy to hear how OneSkin is redefining skin as a living organ—and why the future of longevity may start at the surface.
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In this Fragrance Friday episode of Skin Anarchy, Dr. Ekta sits down with Pissara Umavijani, founder and perfumer of Parfums Dusita, for a quietly powerful conversation about perfume as emotion, memory, and meaning. In an industry increasingly driven by trends and virality, Dusita stands apart as a house built on poetry, patience, and feeling.
Pissara shares her deeply personal journey—leaving Thailand to start over in Paris with a singular intention: to create fragrance that makes people feel. Entirely self-taught, she immersed herself in the craft of perfumery through persistence and intuition, guided by a belief that scent should communicate something human, not perform for attention. Even the name Dusita, which refers to a level of paradise in Thai culture, reflects this ethos—living with purpose, warmth, and emotional presence.
Rather than relying on obvious cultural motifs, Dusita expresses Thai heritage through values: gentleness, hospitality, compassion, and balance. These qualities shape not only the fragrances themselves, but how the brand engages with people—inviting closeness rather than spectacle.
At the heart of every Dusita fragrance is poetry written by Pissara’s late father. Each poem serves as an emotional blueprint, translated into scent rather than illustrated literally. This approach comes to life in beloved creations like Tonka Latte, a soft, comforting gourmand inspired by warmth and love, and Pavilion d’Or, a serene composition that captures balance and stillness without adhering to a single category.
Throughout the conversation, Pissara returns to one guiding principle: balance. For her, great perfumery isn’t about intensity—it’s about harmony, evolution, and restraint. Dusita’s fragrances don’t demand attention; they reward it.
Listen to the full Skin Anarchy episode to hear how poetry, Thai cultural values, and emotional honesty shape Parfums Dusita—and why the most powerful fragrances are often the quietest ones.
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In this episode of Skin Anarchy, Dr. Ekta Yadav is joined by Dr. Yannis Alexandrides and Eva Alexandridis, the husband-and-wife team behind 111 Harley St. and 111SKIN, for a candid, science-forward conversation on regenerative aesthetics, protocol-based skincare, and what longevity really looks like when it’s rooted in medicine—not marketing.
111SKIN didn’t start as a beauty brand. It began in the operating room. Dr. Alexandrides shares how his work in facial plastic surgery led him to develop skincare that could support faster healing and stronger outcomes after surgery—when nothing on the market met his clinical standards. What surprised him most wasn’t just improved recovery, but the long-term transformation in skin quality patients experienced once healing was complete. That insight became the blueprint for translating surgical-grade science into daily care.
A central theme of the episode is maintenance. Procedures, Dr. Alexandrides explains, are only as successful as the skin’s baseline health. Eva expands on this philosophy, emphasizing that 111SKIN was never about instant fixes—it was about training skin to behave better over time. Longevity, in their view, is built through consistency, restraint, and respect for biology.
The conversation also dives into the brand’s measured approach to advanced technologies like exosomes—used as targeted protocols rather than trends—and the broader shift in aesthetics toward regeneration over replacement. From deep plane techniques to micrografting, Dr. Alexandrides explains why modern plastic surgery is moving away from excess and toward preservation.
Throughout the episode, one message remains clear: longevity aesthetics aren’t about changing who you are—they’re about supporting skin health so you can look like yourself, for longer.
Listen to the full episode of Skin Anarchy to hear Dr. Yannis Alexandrides and Eva Alexandridis unpack the science behind 111SKIN, regenerative skincare, and the future of evidence-based aesthetic care.
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In this episode of Skin Anarchy, Dr. Ekta sits down with Natasha Denona for a rare, reflective conversation that traces the creative and philosophical roots of one of modern makeup’s most influential brands. Known for palettes that have become industry benchmarks, Natasha opens up about how her work has always been driven less by trends—and more by intention, education, and respect for the user.

Growing up between science and art shaped everything. Natasha’s mother, a chemist in inorganic chemistry, exposed her early to laboratories, precision, and technical thinking. While chemistry itself didn’t immediately click, the discipline behind it did. That structured curiosity later resurfaced in how Natasha approaches formulation, texture, and product architecture—where creativity is always grounded in control.

Before makeup, there was painting, theater, and dance. Natasha shares how color became both emotional language and psychological tool, first explored through art and stage makeup. That foundation explains why her palettes feel cohesive yet expressive—each one designed as a complete story rather than a collection of random shades.

A defining theme of the episode is education. Natasha doesn’t create products to sit on a shelf; she designs tools that teach. Long before “educational beauty” became a marketing buzzword, her launches embedded technique—guiding users through layering, sculpting, and dimension the way professional artists actually work.

Rather than chasing novelty, Natasha deliberately builds for longevity. Palettes like Biba and Camel weren’t designed for a moment—they were designed to last across ages, skin tones, and styles. Inclusivity, she explains, has always been non-negotiable, not performative. Her decision to launch 52 foundation shades wasn’t strategic—it was personal.

Throughout the conversation, one belief remains constant: the product should be the star. Natasha never wanted her image to overshadow the work itself.

Listen to the full episode of Skin Anarchy to hear Natasha Denona reflect on creativity, inclusivity, and why true innovation in beauty comes from intention—not trends.

SHOP NATASHA DENONA

CHAPTERS:
(0:02) - Welcome & Introducing Natasha Denona
(1:14) - Growing Up Around Science, Art, and Photography
(4:43) - Early Relationship With Color, Makeup, and Expression
(6:11) - From Dance & Modeling to Makeup Artistry
(7:26) - Building Iconic Color Stories & Palette Philosophy
(9:05) - Inclusivity as a Core Creative Principle
(13:19) - Creating Complexion Products at Scale
(17:05) - Longevity, Creativity, and Avoiding Trends
(24:08) - Entrepreneurship, Visibility, and Authentic Leadership

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In this episode of Skin Anarchy, Dr. Ekta sits down with Denise Vasi, founder and creative force behind MAED, for a thoughtful conversation about building beauty with intention, patience, and care. Denise’s path into the industry began early—signed to Ford Models and immersed in on-set artistry long before social media shaped beauty culture. Those formative years, paired with memories of her grandmother’s at-home esthetic rituals, planted the seed for a philosophy rooted in preparation, respect, and craft.

Before MAED ever existed, Denise built something rarer than hype: community. Through years of honest storytelling around wellness, motherhood, and clean living, she created a dialogue with women who trusted her voice. That trust shaped MAED’s slow, deliberate evolution. Rather than chasing trends or speed, Denise chose to listen—developing products only when they solved real, lived problems.

At the heart of the brand is a deceptively complex product: the red lip. Denise unpacks why most formulas fail—dryness, poor undertones, and exclusion baked into development—and how MAED set out to fix that. Comfort came first, followed by rigorous testing across skin tones, lip shapes, ages, and backgrounds. Inclusivity, she explains, isn’t a campaign—it’s formulation, design, and function.

Central to MAED’s ethos is one guiding principle: care before color. Lips lack oil glands and cannot repair themselves without real barrier support. MAED’s formulas focus on hydration, resilience, and wear—so color performs because the foundation is healthy.

Beyond product, the conversation explores beauty as ritual and self-expression. The red lip becomes more than pigment—it’s confidence, protection, and presence.
Listen to the full episode to hear Denise Vasi share the philosophy behind MAED, the science of lip health, and why meaningful beauty innovation starts with care—not trends.

SHOP MAED and learn more on their social media!

CHAPTERS:
(0:02) - Introduction & Welcoming Denise Vasi
(0:59) - Early Career: Modeling, Beauty Sets & Formative Influences
(2:16) - Building Community Through Editorial & Made.co
(4:48) - Slow Beauty, Brand Intention & Resisting Trend Cycles
(7:13) - Reimagining the Modern Red Lip
(8:04) - Formulation, Testing & True Inclusivity
(12:16) - What Inclusivity Really Means in Beauty
(16:30) - Lip Health, Barrier Science & Care-First Formulation
(23:10) - Care Before Color & The Cultural Power of a Red Lip

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