Immune

David Schatz talks about his discovery of Rag genes that are critical for antigen receptor development and how that discovery depended on taking high risks and using approaches that everyone thought could never work.
Host: Cindy Leifer
Guest: David Schatz

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Transfer of recombinase activity in non-lymphoid cells (Cell 1988)
Identification of the RAG-1 gene (Cell 1989)
Evolution of a recombinase (Semin Immunol 2004)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to [email protected]
Information on this podcast should not be construed as medical advice.

The Immune team discusses the groundbreaking discoveries of regulatory T cells, which was the topic of the 2025 Nobel Prize in Physiology or Medicine.
Hosts: Vincent Racaniello, Cindy Leifer, and Brianne Barker
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Sakaguchi lab paper on FoxP3 and regulatory T cells (Science 2003)
Brunkow and Ramsdell description of scurfy mouse mutation (Nature 2001)
Nobel Prize writeup on Treg discoveries
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]
Information on this podcast should not be construed as medical advice.

Susan Schwab talks about how she got the research bug, bugs she ate, and her research on how the lipid S1P helps T cells decide- should I stay or should I go.
Host: Cindy Leifer
Guest: Susan Schwab

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Links for this episode
MicrobeTV Discord Server
Schwab lab website
Monocytes produce the lipid S1P to regulate T cell movement
Review on S1P and immune cell migration
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to [email protected]
Information on this podcast should not be construed as medical advice.

Immune discusses cross-reactive antibodies to avian influenza neuraminidases and a role for gut-derived T cells in the brain to regulate eating behavior.
 
Hosts: Vincent Racaniello, Cindy Leifer, Steph Langel, and Brianne Barker
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Links for this episode
MicrobeTV Discord Server
Antibody cross-reactivity to influenza H5N1 (Cell Host Microbe, 2025)
Gut-derived T cells regulate behavior (Nature, 2025)
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Immune logo image by Blausen Medical

Send your immunology questions and comments to [email protected]
Information on this podcast should not be construed as medical advice.

Kristian Andersen from Scripps Research Institute joins Cindy to talk about how he got interested in virus evolution, how the immune system drives viral adaptation, and what we can learn from this research to better prepare us for the next pandemic.
Host: Cindy Leifer
Guest: Kristian Andersen

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Become a patron of Immune!
Links for this episode
MicrobeTV Discord Server
Andersen Lab website
Perspective on Immunological drivers of virus emergence
Kristian's appearance on TWiV 774
Time stamps by Jolene Ramsey. Thanks!
Music by Tatami.
Logo image by Blausen Medical

Send your immunology questions and comments to [email protected]
Information on this podcast should not be construed as medical advice.