Profile

The inventor of the World Wide Web, Sir Tim Berners-Lee, is celebrating 30 years of his creation. He's also issued a warning that the Web could plunge towards a "dysfunctional future". Mark Coles looks at the life of the pioneering computer scientist. Producer: Phoebe Keane

Nan Goldin is a cultural icon and pioneer of art photography celebrated for her provocative and intimate photos of drag queens, drug addicts and sex. But recently she has been generating headlines not for her art but for her activism. The photographer has been fighting the US opioid epidemic after battling her own addiction to prescription painkillers. CORRECTION: In this edition of Profile we said Nan Goldin has protested on the steps of the Museum of Modern Art. In fact she has protested on the steps of the Metropolitan Museum of Art. Producers: Viv Jones and Tural Ahmedzade Protest audio courtesy of Mike Quinn

CRISPR Cas9 has been described as the greatest biological breakthrough in decades. The hopes resting on this gene editing technology are immense - this week a Swiss drug company announced it is beginning a landmark clinical trial using CRISPR on a patient with a dangerous blood disease. Mark Coles profiles one of the creators of the technology, the American biochemist Jennifer Doudna. Clarification: In 2018 a federal court confirmed that the patents granted by the United States Patent and Trademark Office to the Broad Institute, MIT and Harvard concerning CRISPR editing of eukaryotic genomes do not interfere with patent claims filed by the University of California, Berkeley where Jennifer Doudna is based. A new decision in February 2019 has granted Jennifer Doudna and her team the patent at the heart of this intellectual property dispute. Jennifer Doudna and her team have been granted several substantial patents for CRISPR technology. Presenter: Mark Coles Producers: Viv Jones, Tural Ahmedzade

MP Luciana Berger resigned from the Labour Party this week to join the newly-formed Independent Group. For years she has been the target of sustained anti-Semitic abuse, and has criticised the Labour Party's handling of the issue. One of the reasons she gave for leaving the party is that she has come to view it as "institutionally anti-Semitic”. Her resignation comes within days of her facing a vote of no-confidence in her Liverpool Wavertree constituency, which was withdrawn after a bitter row. Presenter: Becky Milligan Producer: Viv Jones, Tural Ahmedzade Editor: Penny Murphy

The transport secretary's critics call him “failing Grayling" - an unkind nickname, perhaps, but one made more likely to stick by his infamous decision to award a valuable contract to a Brexit ferry company with no ferries. He cancelled the contract this week amid much derision in Parliament. Presenter: Mark Coles Producer; Sally Abrahams